Internal Medicine
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Desmopressin Acetate Nasal Spray (Noctiva)
Desmopressin nasal spray is indicated for the treatment of nocturia due to nocturnal polyuria in adults who awaken at least twice per night to void.
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Polyneuropathy in the Metabolic Syndrome
The metabolic syndrome, independent of the diagnosis of diabetes, is associated with the development of polyneuropathy.
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Pioglitazone Improves Fibrosis Scores in Nonalcoholic Steatohepatitis Patients With and Without Diabetes
In a meta-analysis of eight studies (five pioglitazone, three rosiglitazone) involving 516 patients with biopsy-proven nonalcoholic steatohepatitis, pioglitazone was found to improve fibrosis between six and 24 months.
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Can Magnesium Cure Nocturnal Leg Cramps?
A small randomized, double-blind, placebo-controlled trial demonstrated that oral magnesium oxide was not superior to placebo for older adults suffering from nocturnal leg cramps.
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Infectious Disease Alert Updates
Take Those Pins Out of Your Mouth!; How Many Sex Partners Is “Too Many”?; Rinse that GC Right Out of Your Mouth
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2016 Was Not a Good Year for New FDA Anti-infectives
In 2016, two anti-hepatitis C virus combination drugs were approved, as were monoclonal antibodies directed at bacterial toxins (anthrax toxin and Clostridium difficile toxin B), as well as an oral cholera vaccine.
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Treatment of Early Forms of Syphilis in HIV-Infected Patients
The results of this randomized trial provide support for the CDC recommendation of treatment of early stages of syphilis in HIV-infected patients with a single intramuscular 2.4-million-unit dose of benzathine penicillin.
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A Potpourri of Global Viral Activity — It’s Always Something
Ross River virus, Sindbis virus, Kyasanur Forest disease, Lassa fever, avian influenza, MERS-CoV, and Seoul virus are among the viruses currently causing outbreaks.
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Yellow Fever Redux
Yellow fever currently is epidemic in Brazil, and there is concern of further spread.
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Antibiotic Use in Children — a Cross-national Analysis
Up to 7.5-fold differences in antibiotic use in children were seen across six developed countries in Europe, Asia, and North America. The highest rate of antibiotic use was in Korea, and the lowest was in Norway.