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This report described the results of a double-blind, placebo-controlled study of flupirtine maleate (FLU), a triaminopyridine compound in patients with Creutzfeldt-Jakob disease (CJD). The patients with flupirtine showed significantly less deterioration in the dementia tests than the patients treated with placebo.
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The prospects for therapy in Huntingtons disease are rapidly improving. Another potential treatment is to use striatal neural grafts.
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The availability of comprehensive records of public health in Scandinavian countries is a major advantage in working out epidemiological studies. The present study of Swedish twins including many older than 80 now suggests that the genetic component of AD may be less than previously thought.
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Although beta-blockers are known to reduce the sensitivity of exercise and dobutamine sestamibi SPECT imaging for the detection of coronary artery disease, little is known about their effects on vasodilator stress scintigraphy. Thus, Taillefer and colleagues studied 21 patients with catheter proven coronary artery disease during 3 different treatments on different days assigned in a random fashion.
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A United Kingdom survey of sudden arrhythmic death syndrome in 32 victims aged 4-64 with normal hearts at autopsy and a negative toxicologic screening test evaluated first-degree relatives of these victims.
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In this paper, Oral and colleagues compared 2 current ablation techniques in patients with paroxysmal atrial fibrillation.
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This widely publicized small trial has catapulted the mutant form of ApoA-1 Milano into the limelight. Many investigators have been working with this interesting lipoprotein since it was discovered in the 1980s that 38 carriers from a small village in Northern Italy have very low HDL levels but very little vascular disease.
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What characteristics of a neuropathy make Sjögren syndrome the likely diagnosis?
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In an entirely novel observation, Walz and associates describe a cellular prion protein variant associated with hippocampal sclerosis that seems to be partially predictive of seizure-free outcome in patients undergoing surgery for medically refractory mesial temporal lobe epilepsy.
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In this epidemiologic analysis of 22,312 individuals living in Norway, a total of 87 reported having developed multiple sclerosis. The risk of developing multiple sclerosis was significantly higher among smokers than among never-smokers.
