Internal Medicine
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Should Asymptomatic Patients with Severe Mitral Regurgitation be Referred for Valve Repair?
In patients with severe degenerative mitral regurgitation (MR), surgery is clearly recommended in the presence of any symptoms. -
The Course of Headache in Idiopathic Intracranial Hypertension
In a prospective study of 35 patients with newly diagnosed idiopathic intracranial hypertension confirmed by diagnostic lumbar puncture and treated with standard medication regimens, 43% of patients had excellent headache outcome at 12 months, with the major improvement seen within the first month of diagnosis. -
Is Exercise Harmful in Charcot-Marie-Tooth Disease?
Unlike other neuromuscular disorders, physical exercise does not appear to worsen weakness in patients with Charcot-Marie-Tooth disease. -
Stroke Alert
At least 30% of strokes in China are caused by intracerebral hemorrhage, compared with approximately 10-15% in North America. -
Somatic Mutations in Cerebral Cortical Malformations
Targeted high-coverage sequencing for causal somatic mutations in patients with cortical malformations is more sensitive than traditional Sanger and whole-exome sequencing. -
Varicella-Zoster Virus and Fingolimod: Much Ado about Not Much?
The risk of varicella-zoster virus infections in patients treated with fingolimod is slightly higher than placebo, but is overall quite low. -
Cerebrospinal Fluid ß-Amyloid 42 vs Amyloid PET Imaging in the Diagnosis of Alzheimer’s Disease
Aß 42, measured in cerebrospinal fluid, may help determine whether patients have normal or increased cortical Aß deposition. Additionally, abnormal PET 18F-flutemetamol retention levels correlate with disease stage in patients with mild cognitive symptoms.
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Ethnicity and Treatment of Otitis Media
Nationally, nonblack children with otitis media more frequently receive broad-spectrum antibiotics than black children do. The majority of children with otitis media in the United States receive inappropriate treatment with broad-spectrum antibiotics. -
Should Lumbar Puncture Still Be Routine for Febrile Babies?
Meningitis is very unlikely in otherwise healthy-appearing febrile infants older than 21 days of age. Thus, cerebrospinal fluid analysis might not be needed as part of a “routine” evaluation of these babies. -
Spherusol® — Testing for Dermal Delayed Hypersensitivity to Coccidioides
In the fifth and sixth decades of the 20th century, Charles Smith reported the results of skin testing with coccidioidin, a culture filtrate of the mycelial phase of Coccidioides.