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A systematic review of 9 studies showed that the COX-2 inhibitor celecoxib and ibuprofen cause less upper GI bleeding than other NSAIDs. Diclofenac, meloxicam, ketoprofen, indomethacin, and naproxen have intermediate risk. Piroxicam and ketorolac have the highest risk. In general, drugs that have a long half-life or slow-release formulation have the greatest risk of GI bleeding.
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There is no difference in rates of treatment failure, death, or readmission for COPD between patients treated with oral or intravenous steroids for exacerbation of COPD, but the IV route may be associated with increased cost and length of stay.
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The first receptor activator of nuclear factor kappa-B ligand (RANKL) inhibitor has been approved for the treatment of osteoporosis.
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Fibrates: Generally safe, but do they improve outcomes? According to this meta-analysis, the answer to the question above very much depends upon which outcome you believe is important.
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A recent report described a fatal case of community-acquired C. difficile diarrhea (CDAD) in a patient receiving antibiotics for a questionable diagnosis of chronic Lyme disease.
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A retrospective cohort study was conducted of infants < 6 months of age hospitalized with urinary tract infections between 1999 and 2004 at 24 children's hospitals in the United States.
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In March 2009, 89 active-duty u.s. trainees received yellow fever (YF) vaccination as part of standard preparation for potential travel to sub-Saharan Africa and Central and South America.
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A retrospective observational study was conducted on 30 individuals from a possible 49 persons who were treated for schistosomiasis between 2003 and 2008 at Copenhagen University Hospital, Denmark.
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This subset analysis from a larger prospective, multicenter HIV-HCV coinfection treatment trial found that patients receiving highly active antiretroviral therapy (HAART) in combination with pegylated interferon alfa and ribavirin for HCV were at greater risk for lactic acidosis and hyperlactatemia than those receiving HCV treatment alone.
