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In 1936 Selye noted that rats exposed to stressors had enlarged adrenal glands. In the late 1940s, Kendall and Reichstein isolated cortisone as the active principle of the adrenal glands. In more recent years our understanding of the hypothalamic-pituitary-axis has grown immensely.
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Developing a research survey instrument is a lengthy and complicated process, says Daniel P. Sulmasy, OFM, MD, PhD, of the John J. Conley Department of Ethics at Saint Vincents Hospital in Manhattan. Sulmasy and several colleagues spent five years developing an instrument that elicits ratings of quality and satisfaction with care from medical inpatients, especially those near the end of life.
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The Women's Health Initiatives (WHI) was halted 1 year ago, but fallout from this landmark study continues. The study was designed to identify the risks or benefits of estrogen plus progesterone vs placebo in healthy postmenopausal women.
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This is an elegant study, which examined whether sinovenous obstruction may play a role in idiopathic intracranial hypertension (IIH).
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Congenital myasthenic syndromes (CMS) are present at birth.
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This is a study that examined levels of nitrotyrosine, a specific marker for protein modifications produced by nitric oxide-derived oxidants.
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Hypertension is a major risk factor for both ischemic and hemorrhagic stroke. This and other risk factors for atherosclerosis are not merely issues for middle and late age.
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Anti-ganglioside peripheral nerve antibodies in Guillain-Barré syndrome (GBS) include GM1, asialo-GM1, GQ1b, GD1a, and GT1a. GM1 is associated with pure motor GBS and with the acute motor axonal variant of GBS. GM1b is also associated with GBS, but often its role in the disease is obscured by the concomitant presence of GM1. The role of GM1b in the absence of GM1 remains to be defined.
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Two recent reports strongly suggest that Elans AN-1792 Alzheimers vaccine, which was withdrawn from clinical trials after several Alzheimers disease (AD) patients developed severe brain inflammation, did in fact succeed in altering the course of AD in some cases.
