Internal Medicine
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Widely Used in Asia, Cilostazol Appears Effective for Long-Term Secondary Stroke Prevention
Cilostazol is a phosphodiesterase 3 inhibitor widely used in Asia for secondary stroke prevention but approved for use in North America only for symptomatic peripheral vascular disease. It has been theorized that cilostazol might be beneficial in preventing the progression of small vessel disease in the brain and, therefore, may have a secondary effect in preventing vascular dementia.
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Treatment of Central Retinal Artery Occlusion with Intravenous Thrombolysis
Central retinal artery occlusion is a serious threat to vision caused by interruption of the blood supply to the retina and leading to sudden, painless loss of vision in one eye. For 30 years there have been anecdotal reports and small case series suggesting that intravenous thrombolysis might be beneficial in this disorder, but none of the stroke treatment guidelines have incorporated thrombolysis as definitive treatment for this disorder.
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Anticoagulation in Patients with Ischemic Stroke Related to Atrial Fibrillation, Following Reperfusion Therapy
Following ischemic stroke in patients with non-valvular atrial fibrillation, the timing to restart anticoagulation treatment is uncertain and controversial. In addition, there is little data available regarding timing to restart anticoagulation following reperfusion therapy with either systemic thrombolysis and/or mechanical thrombectomy.
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Brachial Plexopathy Localization in Patients with Cancer
Brachial plexopathy associated with cancer may involve any region of the brachial plexus and can be distinguished from radiation-induced brachial plexopathy only by the use of high-resolution magnetic resonance imaging.
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Clinical Trials of IL-6 Inhibitors for the Treatment of Neuromyelitis Optica Spectrum Disorders
In a randomized, placebo-controlled trial of neuromyelitis optica spectrum disorder patients, satralizumab monotherapy demonstrated a decrease in relapse rate when compared to placebo. In a randomized, open-label, multicenter trial of tocilizumab vs. azathioprine, treatment with tocilizumab demonstrated a decreased risk of a relapse compared to azathioprine.
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White Paper Calls for Overhaul of Federal Nutrition Research
Coalition of experts say extra funding, better coordination needed to improve public health.
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Protect the Brain from Air Pollution with … Fish?
Researchers observed better white matter preservation in those who consumed more omega-3 fatty acids.
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The ABCs of CBD: The Fundamentals of Cannabidiol
Cannabidiol (CBD) is one of two major constituents of marijuana and is the non-psychoactive component of cannabis. As its popularity has grown, questions about CBD from patients to their primary care clinicians have increased dramatically. As a patient advocate interpreting the available evidence, the primary care clinician needs to recognize how CBD differs from marijuana, what its clinical utility might be, and what its risks are.
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Infectious Disease Alert Updates
Metronidazole Neurotoxicity Is Real; 2020 Updated LTBI Treatment Guidelines; Risks of Hookah Smoking