Internal Medicine
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Clascoterone Cream 1% (Winlevi)
Clascoterone should be prescribed to treat acne vulgaris in patients age 12 years and older.
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Respiratory Syncytial Virus: Effective Prevention Still Needed
Prevention of respiratory syncytial virus infection is needed but challenging. New studies show some favorable effectiveness on infant outcomes with both vaccination of healthy pregnant women and passive single-dose immunization of prematurely born babies.
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Is Isolated Diastolic Hypertension a Disease?
An analysis of three large prospective databases showed the 2017 American College of Cardiology/American Heart Association revised definition of isolated diastolic hypertension as > 80 mmHg rather than the previous definition of > 90 mmHg resulted in a 5% higher prevalence of diastolic hypertension.
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Vitamin D and Colon Cancer
A self-report of any vitamin D supplementation was associated with a decrease in colorectal polyps.
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Aromatherapy Reduces Pain and Other Symptoms
In people with myofascial pain syndrome receiving a trigger point injection, aromatherapy with lavender oil helped to decrease pain and anxiety and improve comfort.
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Nuts and Heart Health
This long-term, prospective study looks at changes in quantity of nut consumption and relative risk of cardiovascular disease and finds significantly lower risk when nut consumption increases by > 0.5 servings daily.
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Mahjong and Mild Cognitive Impairment
This randomized, controlled trial notes improvement in measures of executive functioning, such as organization and planning, in elderly Chinese participants with mild cognitive impairment who were selected to play mahjong three times weekly for 12 weeks.
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Gut Microbiome in Patients at Risk for Parkinson’s Disease
Certain risk factors and prodromal markers of Parkinson’s disease (PD), such as constipation and rapid eye movement sleep behavior disorder, are associated with specific bacterial compositions of the gut. However, the value of gut microbiome data to predict the risk of PD development needs further investigation.
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Auditory Startle Response as a Predictor of Recovery from Coma
Preserved habituation of the auditory startle response, performed at the bedside, indicates intact cortical structures and cortico-cortical white matter tract connections. Preservation of this reaction in patients with unresponsive wakefulness can help distinguish the vegetative state from minimally conscious state and may even predict eventual awakening.
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Oral Calcitonin Gene-Related Peptide Antagonist for Prevention of Migraine
Atogepant, an oral calcitonin gene-related peptide (CGRP) antagonist, was shown to be effective and safe for migraine prevention. This adds an additional CGRP antagonist to the growing arsenal of such medications, both oral and parenteral, for both prevention and treatment of migraine.