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FDA Rejects Plan B Bid; Recombinant Erythropoietin Products May Stimulate Tumor Growth; Rosuvastatin: Markets Most Potent Statin; FDA Actions.
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This retrospective study determined that catheter-directed thrombolysis was equally effective and safe whether urokinase, alteplase, or reteplase was used, but that costs were substantially less with the newer recombinant drugs.
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In this randomized, controlled trial, when patients developed recurrent respiratory failure following extubation, the use of noninvasive ventilation delayed but did not prevent reintubation, and this delay was associated with a higher mortality rate in the ICU.
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The gold standard in the era of EBM is the randomized controlled trial (RCT). A properly designed and carried out RCT, in patients similar to those the practitioner manages and using end points relevant to both practitioner and patient, is more likely to be free from bias and to produce results that will stand up over time than other types of investigation such as retrospective analyses, case-control studies, and unsystematic clinical observations.
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Patients who received hyperoxia during general surgery had an increase in surgical site infections compared to those who received a lower oxygen concentration.
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The first part of this series reviews cervical spine immobilization, patient selection for imaging and clinical decision rules for cervical spine radiography. This two-part article is critical for any physician who manages patients with potential cervical spine trauma.
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Part I of this two-part series on stroke covered the differential diagnosis, risk factors, and prevention of stroke. This second and final part in the series will focus on the physical examination, laboratory investigations, imaging, and treatment of stroke.
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Pulmonary embolism (PE) is an illness that frequently presents with nonspecific symptoms, that affects people of all ages and stages of life, and that is difficult to diagnose with available tests. The first article in this two-part series will cover the epidemiology of PE, the factors that increase a patients risk for the disease, and the pathophysiology and clinical features of PE. In addition, complicated issues regarding the diagnosis of PE and the controversies involved will be addressed.
