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A number of retrospective studies have provided evidence that, relative to therapy with semisynthetic penicillins such as nafcillin, vancomycin is inferior in the treatment of bactermic infections due to methicillin-susceptible Staphylococcus aureus (MSSA).
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This interesting study from Denmark used data from the comprehensive Danish Civil Registration System to examine mortality in siblings of HIV/HCV-coinfected patients, HIV-monoinfected patients, and controls.
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Citalopram Useful for Depression in CDA Patients; When to Stop Anticoagulation Before Surgery?; Drug Warnings: Ranibizumab and Bevacizumab; Growth Hormone Treatment, More Harm Than Good; FDA Actions
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In an open label study, hospitalized adults with MRSA colonization at one or more sites were randomized (3:1) to attempted decolonization or no treatment. Treatment consisted of 7 days of bathing with 2% chlorhexidine gluconate, together with application of 2% mupirocin ointment to the anterior nares 3 times daily and administration of rifampin (300 mg twice daily) and doxycycline (100 mg twice daily).
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A 56-year-old man, originally from India and with a history of hypertension, had developed bilateral red, swollen ankles while on a recent trip to Bangalore. Five days later, the patient developed severe fever and shaking chills that resolved within 48 hrs.
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In October of 2005, the first reports of 5 cases and the possible association of Guillain-Barré Syndrome (GBS) and recipients of Menactra® Meningococcal Conjugate Vaccine (MCV4) were reported.
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Segers and colleagues of the University of Amsterdam conducted this randomized, double-blind clinical trial at a 480-bed community hospital that performs 1200 cardiac surgical procedures annually.
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In patients with M. Tuberculosis infection, the emergence of chromosomally mediated resistance to INH is a stochastic process, meaning it is the sum of the product of the spontaneous mutation rate (10-6) and the total bacterial load.
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Status epilepticus, in the setting of cancer, is treatable and does not appear to increase mortality above the risk of the underlying disease.
