Clinical
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Identifying and Treating Skin and Soft Tissue Infections
Skin and soft tissue infections refer to infections that affect the skin and its underlying soft tissues. These infections are classified by the level of skin involvement. The costs associated with Staphylococcus aureus skin and soft tissue infections are estimated at an average of $8,865 for both inpatient and outpatient treatment, and a median charge of $19,984 for hospitalizations. These costs can place a significant burden on both patients and the healthcare system. Timely and accurate diagnosis and treatment can help to reduce this burden, both financially and by decreasing the risk of complications.
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Quality Improvement Project Aims to Decelerate Aggressive Hypertension Treatment
Although there might be good intentions behind administering intravenous antihypertensive medication, staff should remain mindful of possible consequences.
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Fezolinetant Tablets (Veozah)
Fezolinetant can be prescribed to treat moderate-to-severe vasomotor symptoms caused by menopause.
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Adjuvant Systemic Corticosteroid Therapy in Hospitalized Patients with Community-Acquired Pneumonia
In this meta-analysis, all-cause mortality, ICU admission, and incidence of adverse events were similar in patients who received corticosteroids compared to standard care. However, the corticosteroid therapy group recorded a lower incidence of progression to mechanical ventilation.
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Direct Oral Anticoagulants vs. Warfarin When Treating Renal Dysfunction
A patient-level meta-analysis of five pivotal trials of direct oral anticoagulants (DOACs) vs. warfarin for patients with atrial fibrillation and creatinine clearance levels ranging from normal to 25 mL/min revealed standard-dose DOACs exhibit superior safety and efficacy compared to adjusted-dose warfarin and lower-dose DOACs.
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The Best Use of Statins in Patients with Coronary Artery Disease
A randomized, multicenter study of high-intensity statin therapy to a treat-to-target approach in coronary artery disease patients showed no difference in three-year outcomes. These results suggest treating to a target may be more suitable to individual patients compared to blanket high-intensity statin use.
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A Promising Frontier in Alzheimer’s Treatment
In a multicenter, head-to-head trial, donanemab demonstrated superiority over aducanumab for early symptomatic Alzheimer’s disease patients.
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Preconception Hepatitis B and Congenital Heart Disease
A new study suggests that both women and men who have had hepatitis B infection prior to conceiving offspring are more likely to give birth to children with congenital heart disease.
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Maternal, Fetal, and Infant Implications of a Positive Syphilis Screening During Pregnancy
Although syphilis screening during pregnancy is effective in identifying maternal syphilis, it is not without consequences. False-positive syphilis testing can result in unwarranted antibiotic therapy; re-screening based on risk is not always consistent, and among pregnant women who truly test positive to syphilis, treatment is not always optimized to prevent congenital syphilis.
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Barriers to Urogynecologic Care
There is a paucity of literature on barriers to urogynecologic care in racial/ethnic minorities. Continued evaluation is needed to better understand the unique barriers to urogynecologic care in these populations.