Clinical
RSSArticles
-
An RNA Shot for Hypertension?
One dose of a new RNA-based drug administered by subcutaneous injection, which blocks hepatic angiotensinogen production, resulted in sustained reductions in blood pressure in patients with hypertension for up to 24 weeks without any serious adverse effects.
-
Is the Combination of a GLP-1 Agonist and a SGLT2 Inhibitor Safe?
Adding a GLP-1 RA in a subgroup of type 2 diabetes patients on baseline SGLT2 inhibitor therapy revealed GLP-1 RA reduces major adverse cardiovascular event rates, regardless of baseline SGLT2 use.
-
The Hemodynamic Effects of an SGLT2 Inhibitor in Heart Failure with Preserved Ejection Fraction
The authors of a small, placebo-controlled study of 24 weeks of dapagliflozin therapy in patients with heart failure with preserved ejection fraction reported reductions in pulmonary capillary wedge pressure, which may explain the reductions in heart failure hospitalizations or cardiovascular death in larger randomized outcome trials.
-
High-Impact Clinical Trials from the European Society of Cardiology Congress 2023
The following is an overview of important cardiology research presented Aug. 25 through Aug. 28 in Amsterdam and online during the ESC Congress 2023.
-
Is Planned Complete Revascularization After Myocardial Infarction Wise for Older Patients?
Among patients at least age 75 years presenting with acute myocardial infarction and multivessel coronary disease, physiology-guided complete revascularization led to a lower risk of major adverse cardiovascular events at one year vs. culprit lesion-only percutaneous coronary intervention.
-
Supine Blood Pressure Readings May Reveal Hidden Health Risks
Measuring a patient’s blood pressure while he or she is lying down could help clinicians learn more about possible underlying heart problems.
-
Syncope and Complete AV Block?
The rhythm strip shown in the figure was recorded from a patient with syncope. It was interpreted as consistent with complete AV block. Do you agree with that interpretation?
-
Zuranolone Capsules (Zurzuvae)
Zuranolone can be prescribed to treat postpartum depression.
-
The Degree of Pyuria Can Help Determine Urinary Tract Infection in Elderly Women
Elderly women with a urinary tract infection recorded a higher median number of urinary leukocytes compared to uninfected controls, including those with asymptomatic bacteriuria. For 264 leukocytes/µL, the sensitivity and specificity of microscopy were 88%. Using the standard pyuria threshold of 10 leukocytes/µL gave a specificity of 36% and a sensitivity of 100%.
-
Treating Psychotic Symptoms Among Alzheimer’s Disease Patients
In a meta-analysis of several large treatment trials of patients with Alzheimer’s disease, Parkinson’s disease, and dementia with Lewy bodies, cholinesterase inhibitors demonstrated a small but statistically significant benefit in alleviating psychotic symptoms.