Clinical
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Apixaban Dose in Atrial Fibrillation Patients with Chronic Kidney Disease
A large nationwide health systems database study comparing 5 mg apixaban vs. 2.5 mg twice daily in patients with stage 4/5 chronic kidney disease not on dialysis shows that the 5 mg dose increases the risk of bleeding compared to 2.5 mg without any improvement in the risk of stroke, systemic emboli, or death.
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Slow-Wave Sleep and Risk of Dementia
In this long-term observational study of sleep efficiency in the Framingham Heart Study population, researchers found a strong correlation between a decline in duration of slow-wave sleep during aging and the risk of incident dementia from all causes. However, a direct cause-and-effect relationship cannot be determined from this observational study.
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Peak SARS-CoV-2 Viral Loads Delayed
In an effort to characterize the hypothetical utility of rapid COVID-19 antigen kits, the authors of this study examined cycle threshold values in symptomatic adults infected with SARS-CoV-2 relative to the onset of symptoms.
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Who Benefits Most from Tirzepatide Among Patients with Type 2 Diabetes?
Females, patients of white or Asian race, younger patients, and those taking metformin benefit the most from treatment with tirzepatide.
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Study: Pharmacist Prescribing of Contraceptives Not Working as Well as Intended
Although 20 states have passed policies to allow pharmacists to prescribe short-acting hormonal contraception, these services are not used much, new research suggests.
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Society of Family Planning Issues Clinical Recommendation for Medication Abortion
As maternity and OB/GYN deserts spread across the United States, medication abortion to expel the fetus and placenta from the uterus without a surgical procedure is possible and can work safely and well between 14 weeks and nearly 28 weeks of gestation. There are few absolute contraindications to medication abortion from 14 to 27 weeks of gestation, according to the Society of Family Planning and Society of Maternal-Fetal Medicine’s new clinical recommendation.
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Patients May Desire Contraception Even When Ambivalent About Pregnancy Within a Year
Asking patients about their pregnancy intention might not be the best barometer for whether they want contraception. New research revealed that women who had not had sex with a man in the last month or longer, women who said they wanted to become pregnant in the next year, and women who were ambivalent about preventing pregnancy also said they wanted contraception now.
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The ACA’s Contraceptive Mandate Is Failing to Ensure Free Access to LARC
The Affordable Care Act mandates employers and payers to provide free contraception, including long-acting reversible contraception. But the authors of a new study found that the proportion of people paying $0 for most contraceptive methods declined between 2014 and 2020.
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What Do We Need to Learn About Oral Contraceptives?
In this Q&A, Elizabeth Hampson, PhD, a professor in the department of psychology and core member of the graduate program in neuroscience at Western University in London, Canada, discussed what is needed in reproductive health research.
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Research Sheds Light on Depression, Cognitive Issues, and Hormonal Contraception
More research is needed to learn how hormonal contraceptives affect the brain — both cognition and depression. Recent studies suggest some actions that may be beneficial.