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Restless Legs Syndrome and Post-polio Syndrome

Restless legs syndrome is prevalent in patients with post-polio syndrome and is associated with decreased quality of life and fatigue.

Are Atrial Premature Complexes Benign?

Atrial premature complexes (APCs) are commonly observed on routine ECGs and believed to be harbingers of atrial fibrillation, especially in patients with cardiovascular disease.

Update in Treating Neuropathic Pain

In an exhaustive review of the literature with a meta-analysis, the following medications were found to be most efficacious in the treatment of neuropathic pain: gabapentin, pregabalin, serotonin-noradrenaline reuptake inhibitors including duloxetine or venlafaxine, and tricyclic antidepressants.

Is it Time to Give Up on Systemic Cooling in ST Segment Elevation MI?

Systemic hypothermia as a means to protect against tissue damage is a strategy that has found its way into clinical practice guidelines in the post-cardiac arrest population, in which cooling has demonstrated a neuroprotective effect in multiple contemporary clinical trials.

Angiotensin Receptor Blockade, Renal Function, and Outcomes in Chronic Heart Failure

Renin-angiotensin-aldosterone (RAAS) blockade is an important component of guideline-recommended therapy for heart failure with reduced ejection fraction (HFrEF).

‘The Butterfly Effect’ Explains Weather Triggering of Migraine

For about 13% of patients with migraine, a change in weather may be a trigger for some headaches; however, there is no specific perturbation in meteorological measures that is likely to predict a headache.

Autologous Hematopoietic Stem Cell Transplant for Relapsing-Remitting MS

Interim analysis at 3 years post-treatment of a study of high-dose immunosuppression and autologous hematopoietic stem cell transplant for relapsing remitting-multiple sclerosis demonstrates sustained disease control but also shows potential risks associated with this treatment.

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