Clinical
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Beta-blocker, Shmeta-blocker…Or Are There Important Differences?
Whether clinicians should choose pharmacotherapy based on central BP effects has not been confirmed, although hypertension guidelines throughout the world have increasingly recognized the inadequacy of traditional beta-blockers in comparison to most other classes of agents and relegated them to a lower position on the therapeutic ladder.
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Initial Orthostatic Hypotension: An Under-Recognized Form of Orthostatic Hypotension
Initial orthostatic hypotension represents a population at risk for falls, which may be missed with traditional methods of orthostatic BP measurement.
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Delay in Diagnosis of Hepatocellular Carcinoma
Diagnostic delays are common among patients with hepatocellular carcinoma. -
A Glimmer of Hope for Beta-Blockers in Heart Failure from Diastolic Dysfunction
Because these data are observational in nature, they cannot definitively establish whether beta-blocker treatment reduces mortality in d-CHF, but they provide strong impetus to perform a large randomized trial to ultimately answer the question. -
Left Atrial Appendage Closure: Another Possible Interventional Fix for Atrial Fibrillation
Left atrial appendage closure may be another reasonable option for reduction of stroke risk in atrial fibrillation. -
Can You Make ‘Flat’ Basal Insulin ‘Flatter?’
For patients incurring problematic episodes of hypoglycemia, an insulin that provides even “flatter” plasma levels may provide an advantage.
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FDA Actions
The FDA has approved two drugs for the treatment of diarrhea-predominant irritable bowel syndrome.
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Addition of Ezetimibe to Simvastatin May Improve CV Outcomes
A new study suggests the addition of ezetimibe to simvastatin may improve cardiovascular outcomes in patients with acute coronary syndrome, although the effect is modest.
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Beta-blockade Use in Non-cardiac Surgery Patients
Perioperative beta-blockade appears to be beneficial for patients with high cardiac risk factors undergoing NCS, but it increased the risk of death in those with no cardiac risk factors.
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ECG Review: Is There Complete AV Block or Any Block at All?
We summarize the five parameters to assess in the interpretation of any cardiac rhythm by the saying, “Watch your Ps and Qs — and the 3Rs.”