Clinical
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Nerve Biopsy for Asymptomatic Vasculitic Neuropathy
Nerve biopsy is a safe and highly sensitive definitive diagnostic test for systemic vasculitis, even without symptoms of peripheral neuropathy, when electrodiagnostic tests indicate an axonal neuropathy.
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Migraine and Cognitive Dysfunction
During an attack of migraine without aura, patients may experience transient cognitive impairment, with predominant involvement of verbal processing speed, learning, and memory, due to reversible cortical dysfunction.
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RYR1-related Myopathies
Ryanodine receptor gene mutations are among the most common genetic disorders found in a variety of congenital myopathies, both mild and severe.
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A Modern Epidemiologic View of Status Epilepticus in the United States
In this retrospective review of mortality and hospitalization related to status epilepticus from 1999 to 2010, the authors found that overall mortality remained relatively stable, whereas the rate of related hospitalizations significantly increased, particularly in patients who were intubated and in whom status epilepticus was not the primary diagnosis.
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Infectious Disease Alert Updates
HPV on that Ultrasound Probe? and Saving Elephants from Herpesviruses
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Squirrels as the Source of a New Viral Cause of Encephalitis
Evidence indicates that a newly discovered bornavirus caused infection in squirrels and was transmitted from them to three humans who developed encephalitis and died.
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Scrub Typhus and the Brain
Scrub typhus infections involve the nervous system in a majority of cases and should be suspected in patients who live in, or are returning from, endemic regions with a compatible clinical syndrome.
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Decreasing Cross-Transmission of Carbapenemase-Producing Enterobacteriaceae
A bundled infection control intervention was shown to decrease cross-colonization, prevalence, and bloodstream infection of Klebsiella pneumonia carbapenemase-producing Enterobacteriaceae in long-term acute care hospitals, which may have far-reaching effects into the ICU.
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GAD Antibody Syndromes: When to Dig Deeper
This retrospective case series identifies the clinical and immunologic features of GAD antibody-positive patients who should be screened for an underlying cancer.
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When Profiling Is a Good Thing: Distinguishing Bacterial from Viral Infection
Transcriptional analysis outperformed serum procalcitonin in distinguishing viral from bacterial infections.