Clinical
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Good News for a Change: No Association of Hormonal Replacement Therapy with Breast Cancer Before Age 50
Using data from the Two Sister Study, investigators found no association of past combined hormone replacement therapy with young-onset (before age 50) breast cancer, and a protective effect with estrogen-only therapy.
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Handheld Ultrasound for Assessing Fetal Size
A recent study has shown abdominal circumference assessments with a portable handheld ultrasound machine to be superior to standard fundal height measurements in the prediction of small for gestational age and large for gestational age fetuses in utero and infants at birth.
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Clinical Briefs
In this section: Reconsidering the value of oral nutritional supplementation in patients admitted for COPD; recognizing a relationship between asthma and obesity; and weighing the benefits of sound stimulation in Alzheimer's patients.
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Eluxadoline Tablets (Viberzi) and Rifaximin (Xifaxan) Tablets
Both drugs appear to provide modest benefit in irritable bowel syndrome with diarrhea.
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Statin Use and Cognitive Effects: Not a Brain Drain
A meta-analysis of data from more than 28,000 patients enrolled in 18 randomized, placebo-controlled trials of statin therapy failed to show a causal relationship between treatment and adverse neurocognitive effects for patients with and without cognitive impairment.
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Prostate Cancer and Smoking: One More Reason to Trash the Tobacco
Study showed that following prostatectomy for cancer, smokers and ex-smokers had a higher risk of recurrence.
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You Are What You Feed Your Gut Microbiome
There is mounting evidence that the gut microbiome influences the immune system and the central and peripheral nervous systems.
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Serum Chloride Level Predicts Mortality in Acute Heart Failure
Serum chloride levels measured during hospitalization for acute decompensated heart failure are independently and inversely associated with long-term mortality, independent of serum sodium levels.
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New Study Calls for Caution in Use of Triple Anticoagulant Therapy
Approximately one in four older patients with atrial fibrillation undergoing percutaneous coronary intervention for acute myocardial infarction were discharged on triple therapy, which was associated with higher rates of major bleeding without a measurable benefit in terms of major adverse cardiac events.
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RITA-3 Reports 10-year Mortality Outcomes: Time to Rethink the Guidelines, or Much Ado About Nothing?
The mortality benefit of the routine early invasive strategy seen at 5 years is attenuated at later follow-up, suggesting further trials of more contemporary treatment strategies in non-ST elevation acute coronary syndromes are needed.