Clinical
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Rivaroxaban in the Real World
A large Phase IV registry study shows that rivaroxaban is associated with a very low incidence of major bleeding, death, or stroke. Also, adherence to therapy was much higher than observed in other studies with vitamin K antagonists. -
Delaying Intubation in Severe Alcohol Withdrawal
Delaying intubation until aspiration or cardiopulmonary decompensation did not affect mortality but increased the incidence of pneumonia and length of stay. -
Cerebral Microbleeds Are Risk Factor for Symptomatic Intracerebral Hemorrhage in Patients Undergoing IV Thrombolysis
Cerebral microbleeds, as visualized on gradient-echo or susceptibility-weighted MRI, are considered markers of bleeding-prone cerebral microvessels and constitute a significant and independent predictor of future intracerebral hemorrhage.
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Which Patients with TIA Are at High Risk for a Recurrent Cerebral Vascular Events?
Recurrent cerebral vascular events are one of the main determinants of outcome in patients after minor strokes and transient ischemic attacks.
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Dual Antiplatelet Therapy Appears More Effective Than Single Therapy
How long should duel antiplatelet therapy after stroke or transient ischemic attack last?
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Epidemiology of Neuromyelitis Optica Spectrum Disorders in Two Distinct Populations: Black and White
Based on an epidemiological study in two ethnically and geographically distinct populations of patients diagnosed with central nervous system inflammatory demyelinating diseases, the authors report a higher prevalence among Afro-Caribbean patients in Martinique in the eastern Caribbean sea vs. a predominantly Caucasian population in Olmstead County in Minnesota. The study demonstrates a propensity for neuromyelitis optica to affect blacks more than Caucasians.
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Blood-Based Biomarkers in the Evaluation of Alzheimer’s Disease
At the present time, no blood-based biomarkers have been identified as reliable indicators of A-beta amyloid deposition in the brain.
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Greater Weight Loss Later in Life Is Associated with Increased Risk of Mild Cognitive Impairment
In a population-based, prospective study of subjects 70 years of age or older, increasing weight loss per decade from midlife to late-life was associated with an increased risk of incident mild cognitive impairment.
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Do Miller Fisher Syndrome, Guillain-Barré Syndrome, and Bickerstaff Encephalitis Overlap?
All three of these syndromes — Miller Fisher, Guillain-Barré, and Bickerstaff encephalitis — occur following an acute gastrointestinal infection, with many cases of overlap syndromes, and deficits may progress during the first few days of illness.
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Treatment of Glioblastoma in Elderly Patients
In a retrospective cohort study of elderly patients with glioblastoma, overall survival was superior with combined-modality therapy (radiation and chemotherapy) compared with chemotherapy alone or radiation alone.