Clinical
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Searching for Answers on Knee Osteoarthritis
Data consistently show that for knee osteoarthritis, weight loss is associated with symptomatic and functional improvement. The mechanism of this is incompletely understood, since weight loss has not been shown to affect the progressive degradation of cartilage typical of osteoarthritis.
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New Pharmacologic Direction for Parkinson’s Disease
Most clinicians are used to thinking about dopamine modulation when considering treatments for Parkinson’s disease. Unfortunately, none of the current treatments can be designated as disease-modifying, even though such treatment provides transient symptomatic relief.
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Morphine in Dyspneic Acute Heart Failure
Based on recent data, clinicians should avoid morphine use in acute heart failure patients.
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CV Benefits of GLP-1RA Treatment in Type 2 Diabetes
Among the sodium-glucose cotransporter 2 inhibitor and glucagon-like peptide-1 receptor agonist classes of pharmacotherapy, there appears to be much more similarity than not. Should clinicians consider these salubrious cardiovascular effects a class effect? That is, should all members of the class be anticipated to experience similarly favorable cardiovascular outcomes?
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Are Right-sided Leads Needed?
The ECG in the figure was obtained from a man in his 50s who presented with new severe chest pain. How would you interpret this tracing? What area(s) of the heart are involved? What is the likely culprit artery?
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Clinical Briefs
In this section: opioid-induced nausea; considering the safety of proton pump inhibitors; and life after bariatric surgery.
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Secnidazole Oral Granules (Solosec)
Secnidazole is indicated for the treatment of bacterial vaginosis in adult women.
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Oily Fish Is Associated With Better Sleep
A study in Ecuador showed a strong positive correlation between dietary oily fish intake and sleep quality.
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A Rivaroxaban/Daily Low-dose Aspirin Combination and Cardiovascular Events
The addition of rivaroxaban to daily low-dose aspirin resulted in fewer cardiovascular outcomes and increased major bleeding compared to aspirin alone in patients with stable cardiovascular disease.
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A Cup of Coffee May Help Patients Live Longer
In a prospective cohort of patients coinfected with HIV and hepatitis C virus, drinking three or more cups of coffee per day halved the all-cause mortality risk.