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Which Is Better for Nonconvulsive Seizures: Lacosamide or Fosphenytoin?
Intravenous lacosamide was found to be noninferior to fosphenytoin in the treatment of nonconvulsive seizures in a prospective, multicenter, randomized clinical trial.
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Therapeutic Strategies for Hypertension
This article on hypertension will cover treatments (pharmacological and nonpharmacological), initial therapy, relationship to various disease conditions (diabetes, ischemic heart disease, heart failure, chronic kidney disease, cerebrovascular disease, ischemic stroke, stroke prevention, atrial fibrillation, valvular heart disease, aortic regurgitation, sexual dysfunction), resistant hypertension, hypertensive crises and emergencies, preoperative management, and adherence strategies.
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Instantaneous Wave-free Ratio vs. Fractional Flow Reserve: Defining Low-risk Population for Deferral of PCI
Researchers recently found that deferral of percutaneous coronary intervention based on fractional flow reserve and instantaneous wave-free ratio is equally safe, with a low one-year major adverse cardiac event rate of approximately 4%.
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Substance Abuse and Myocardial Infarction
Among patients ≤ 50 years of age with first myocardial infarctions, use of cocaine or marijuana increased the likelihood of an ST-segment elevation myocardial infarction and the subsequent risk of all-cause and cardiovascular mortality.
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Risk of Infective Endocarditis Revisited
In a comparison of patients with infective endocarditis (IE) and either bicuspid aortic valve (BAV) or mitral valve prolapse (MVP) vs. other IE patients at high or low to moderate risk of IE, BAV and MVP patients were more likely to exhibit viridans streptococci group infections of suspected odontogenic origin and cardiac complications at similar rates to high-risk patients.
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Home-based Detection of Undiagnosed Atrial Fibrillation
In patients with risk factors for atrial fibrillation, screening with a self-applied wearable ECG patch resulted in significantly increased rates of new atrial fibrillation diagnoses within four months, along with greater use of anticoagulants and healthcare resources.
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Canagliflozin Reduces Risk of Heart Failure Hospitalizations for Diabetic Patients
In type 2 diabetes mellitus patients with a higher risk of cardiovascular disease, canagliflozin lowered the risk of cardiovascular death or heart failure hospitalization. Patients with pre-existing heart failure may experience even greater benefit.
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Infectious Disease Alert Updates
Risk Behavior and Toxoplasma; Embolic Risk and Vegetation Size; Recertification: Is There a Better Way?
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Eosinophilic Meningitis Caused by Angiostrongylus cantonensis in the United States
Excluding Hawaii, eosinophilic meningitis due to the rat lungworm rarely is encountered in the United States. Ordinarily, the infection is acquired in Asia and the South Pacific, but it also may be acquired in the southern United States.
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Inappropriate Outpatient Antibiotic Prescribing: The Need to Target Urgent Care Centers
Urgent care centers, which are part of a growth industry, are responsible for a large proportion of antibiotic prescriptions, including inappropriate prescriptions for acute respiratory diagnoses.