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Severe Sepsis and Septic Shock Early Management Bundle
When the Severe Sepsis and Septic Shock Early Management Bundle was used to identify patients with severe sepsis or patients in septic shock, delays in lactate measurements for patients with abnormal lactate levels were associated with delayed initiation of antibiotic therapy and increased mortality.
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Healthcare-associated Infections — Better, But Not There Yet
One-day prevalence studies demonstrated that there has been a 16% reduction in the risk of healthcare-associated infections from 2011 to 2015.
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Oral Linezolid for Staphylococcus aureus Bacteremia
Investigators evaluated 135 patients with Staphylococcus aureus bacteremia (SAB) in a prospective cohort study comparing early switch to oral linezolid to continued treatment with standard parenteral therapy (SPT). Patients with complicated SAB and osteoarticular infection were excluded. Early switch to oral therapy yielded similar outcomes to continued SPT and allowed earlier hospital discharge.
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Factors Associated With Urinary Tract Infections Caused by Multidrug-resistant Gram-negative Bacteria
A multicenter, retrospective, cohort study from southern and eastern Europe identified predictive factors for multidrug-resistant complicated urinary tract infections (cUTI), which included male sex, cUTI acquisition in a healthcare facility, presence of a Foley catheter, having a UTI in the previous year, and receiving an antibiotic in the preceding 30 days.
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Blastomycosis (But Not That Blastomycosis) in the Western United States
Blastomycosis occurs in western Canada and in the United States well outside the known endemic area, but it is due to Blastomyces helicus, not Blastomyces dermatitidis.
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Optimal Treatment of Vivax Malaria
In glucose-6-phosphate-dehydrogenase-sufficient individuals in Southeast Asia, combined treatment with chloroquine and primaquine provides much more lasting relief from vivax malaria than either chloroquine alone or artesunate.
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Venous Thromboembolism Risk After Abortion
Women experience a two-fold increase in risk of venous thrombosis (relative to nonpregnant women) following induced abortion, but a more than six-fold overall reduction in risk of thrombosis compared to women who continue the pregnancy to term.
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Help-seeking Behavior for Pelvic Floor Dysfunction
Women are more likely to seek help for pelvic floor symptoms if they have increased bother and are less likely to seek help if they perceive their symptoms as normal.
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Opportunistic Salpingectomy at the Time of Cesarean Delivery for Postpartum Permanent Contraception
In this retrospective cohort study, almost 20% of women who desired bilateral complete salpingectomy for permanent contraception at the time of cesarean delivery could not undergo the procedure because of adhesions or engorged vasculature.
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Are There Risks With Early-term Birth?
The authors of a multicenter study suggest that composite neonatal outcome is worse when pregnancy is interrupted in uncomplicated pregnancies at 37 to 38 weeks, even with documented fetal lung maturity, compared to pregnancies delivered at full term (39 to 40 weeks).