Clinical
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Comparing Medications Used for Lactation Inhibition
A randomized controlled trial demonstrated superior efficacy of cabergoline compared to pyridoxine (78% vs. 35%; P < 0.001) at suppression of lactation seven days after delivery.
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How Common Is Cardiovascular Disease in Pregnant and Postpartum Women from Socioeconomically Disadvantaged Backgrounds?
Neighborhood-level socioeconomic inequities in early pregnancy were associated with higher risk of long-term cardiovascular disease in pregnant and postpartum women.
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Maternal Mortality in the United States Is Worse than in any Other High-Income Nation
This article compares U.S. maternal mortality to other nations and explores reasons why mortality in the United States is four to 10 times higher than in peer countries.
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Pivmecillinam Tablets (Pivya)
The U.S. Food and Drug Administration (FDA) has approved a new antibacterial for the treatment of uncomplicated urinary tract infection (UTI) in female adults.
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Respiratory Syncytial Virus or Influenza in Older Patients: Which Is Worse?
In individuals 75 years of age or older, respiratory syncytial virus infection was associated with more severe illness than was influenza virus infection.
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Avian Influenza A(H5N1) — From Birds to Cows to Human Infection
The spread of influenza H5N1 in dairy cows with documentation of a human infection raises pandemic concern.
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Is Weight Loss the Key to Heart Health?
The second trial of semaglutide in obese patients with heart failure and preserved left ventricular ejection fraction, this one in people with type 2 diabetes, also has shown significant improvements in symptoms and exercise function with significantly fewer adverse effects than placebo-treated patients.
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It Is Never Too Late: A Systematic Review of Lifestyle Interventions for Cognitive Preservation in the Oldest-Old
This systematic review reveals the importance of a healthy diet rich in fruits and vegetables, along with regular leisure and physical activities, to maintain cognitive functioning in the oldest-old, individuals older than 80 years of age.
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Disorders of Immunity Are a Risk Factor for Herpes Simplex Virus Encephalitis
The current study of herpes simplex virus (HSV) encephalitis demonstrated an association of encephalitis with preexisting autoimmune disease and/or exposure to immunosuppressive and immunomodulatory medications. The findings underscore the potential underestimation of antecedent immune-related dysregulation in HSV encephalitis cases to date.
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Efgartigimod for Seronegative Myasthenia Gravis
In an uncontrolled, open-label series of patients with myasthenia gravis, double antibody-negative patients responded to immunosuppressive therapies in a similar manner as do those with antibodies to acetylcholine receptors (AChR) or muscle-specific tyrosine kinase. However, when treating myasthenia patients with a specific agent (efgartigimod) that blocks AChR antibodies at the level of endothelial cells, double antibody-negative patients do not respond as well.