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Transcatheter Mitral Valve Replacement

A large registry study of transcatheter mitral valve replacement showed excellent results in failed bioprostheses but less overall success in failed mitral valve repairs with rings and conditions associated with mitral annular calcium.

Early Cardiac Catheterization After Resuscitation From Cardiac Arrest

In this first-ever randomized trial about comatose patients without ST-segment elevation who have been resuscitated from cardiac arrest, immediate coronary angiography showed no benefit over delayed coronary angiography in terms of 90-day survival.

Team-Based Approach Associated With Better Outcomes in Cardiogenic Shock

Implementation of a standardized, team-based approach to cardiogenic shock resulted in improved 30-day survival compared to historical controls.

Brexanolone Injection (Zulresso)

Brexanolone is indicated for the treatment of postpartum depression.

Update on Treatments for Vulvovaginal Atrophy

As with many clinical conditions, the spectrum of genitourinary syndrome of menopause requires the clinician to consider the effect on the patient’s quality of life. Although situational lubricants and regular moisturizers effectively pacify many symptoms, local estrogen is a safe, effective, and affordable way to treat the vulvovaginal changes of menopause.

Imagine: Multidrug-Resistant Acute Gonococcal Infection

What would happen if clinicians lost ceftriaxone as an effective therapy for gonococcal infection?

Probiotics Do Not Prevent C. difficile Infection in Hospitalized Patients

A retrospective cohort study from a single California hospital revealed the administration of probiotics to patients receiving antibiotics did not reduce the incidence of healthcare facility-onset Clostridioides difficile infection.

Does Physical Activity Lower the Risk of Parkinson’s Disease?

A systematic review and meta-analysis incorporating more than 500,000 subjects revealed that moderate to vigorous physical activity is associated with a significant reduction in development of Parkinson’s disease; this relationship is most pronounced in men.

Thank You, John Hobbins; Welcome Camille Hoffman

Should All Pregnant Women Be Screened for Hepatitis C?

In this cost-effectiveness analysis using Markov modeling, investigators found that universal antenatal screening for hepatitis C was cost-effective, with a mean incremental cost-effectiveness ratio of approximately $3,000 per quality-adjusted life years gained compared to risk-based screening.