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A Combination of Both SIRS and SOFA Scores Enhances Recognition of Sepsis in the Emergency Department
Compared with either score alone, using both SIRS and SOFA scores led to earlier and more complete recognition of sepsis in patients presenting to the emergency department.
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Effect of Stress Ulcer Prophylaxis Choice on Mortality in Mechanically Ventilated Adults
Proton pump inhibitors reduce the risk of clinically important bleeding, but they may have no effect on the risk of 90-day mortality compared to histamine-2 receptor antagonists.
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Palliative Care and Ethical Considerations in the COVID-19 ICU
The COVID-19 pandemic has created an ICU environment different from what we have ever seen in our lifetimes that has deep palliative care and ethical repercussions.
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Guidance Document Includes Tips for Making Clinical Research More Inclusive
The COVID-19 pandemic has put the spotlight on many problems, including the lack of diverse trial participant populations.
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Etonogestrel Contraceptive Implant and VTE in Postpartum Women
In this national retrospective cohort study of postpartum women, use of the etonogestrel contraceptive implant immediately postpartum was not associated with an increased rate of readmission for venous thromboembolism within 30 days of delivery.
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Maternal and Pregnancy Characteristics Associated with Periviable Interventions
In this case control study using U.S. live birth records between 22 and 23 weeks of gestation, maternal intervention was positively associated with increasing maternal age, Medicaid use, preeclampsia, birth defects, twin gestation, multiparity, and infertility treatments while being negatively associated with non-Hispanic Black race. Positive associations for neonatal intervention included non-Hispanic Black race, preeclampsia, Medicaid use, infertility treatments, less than a high school education, increasing maternal age, and twin gestation, and negative associations included birth defects and small for gestational age pregnancies.
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Apical Suspension at the Time of Vaginal Hysterectomy
The main objective of this study was to determine whether the use of apical suspension at the time of vaginal hysterectomy varies by surgeon specialty.
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Is Vaginal Progestogen Equivalent to Intramuscular Progestogen for Preventing Preterm Birth in High-Risk Women?
In this open-label, equivalence randomized trial of vaginal progestogen compared to intramuscular progestogens for preventing preterm birth in high-risk women, the difference in the risk of preterm birth at < 37 weeks of gestation between both groups was 3.1% (95% confidence interval, -7.6% to 13.8%), which was within the equivalence margin of 15% used in the study.
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Is Isolated Diastolic Hypertension a Disease?
An analysis of three large prospective databases showed the 2017 American College of Cardiology/American Heart Association revised definition of isolated diastolic hypertension as > 80 mmHg rather than the previous definition of > 90 mmHg resulted in a 5% higher prevalence of diastolic hypertension. This was not significantly associated with cardiovascular disease outcomes.
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What to Do with Large Pericardial Effusions
An observational study of patients with chronic, large, hemodynamically insignificant, C-reactive protein-negative, idiopathic pericarditis in which the majority were treated by pericardiocentesis or surgical drainage showed most patients treated conservatively remained stable. The invasive approach did not reveal an etiology for the effusions.