Clinical
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The Effect of Antiviral Drugs on COVID-19 Outcomes and Mortality
The WHO Solidarity Trial Consortium found that remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had “little or no effect” on relevant outcomes. -
Prone Positioning May Improve Outcomes for Patients on ECMO for Severe ARDS
In patients on venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome, prone positioning is safe and feasible. Prone positioning appears to improve survival but increases length of stay. -
Ethics in the ICU: Negotiating Requests for Inappropriate Treatments
When requests for potentially inappropriate treatments occur, the initial steps include increasing communication and improving mutual understanding to find a path that is appropriate while honoring the goals and concerns expressed by patients and their families. -
FDA, CDC Back COVID-19 Vaccine for Adolescents
The Pfizer/BioNTech solution will be available for Americans age 12 to 15 years. -
Report: U.S. Nurse Workforce to Play Pivotal Role Over Next Decade
National Academy of Medicine calls on extra funding, more comprehensive education, and expanded practice authority. -
Is a Vacuum-Induced Device Effective for Control of Postpartum Hemorrhage?
In this multicenter study across 12 centers in the United States, a vacuum-induced intrauterine device successfully treated 94% of participants who experienced a postpartum hemorrhage with a median time of three minutes to control of bleeding.
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Anticholinergic Use for Three Months or More Increases Dementia Risk
There is a significant increase in dementia risk associated with the use of anticholinergic medications for three months or longer.
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Does Maternal BMI Influence the Success of Trial of Labor After Cesarean?
In this retrospective cohort study between May 2007 and April 2016, women undergoing a trial of labor after cesarean (TOLAC) were analyzed to determine if pre-pregnancy or delivery obesity status made an impact on TOLAC success. Overall, maternal body mass index did not have a significant effect on TOLAC success rates.
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Tranexamic Acid for the Prevention of Obstetric Hemorrhage
In this prospective, cohort, pharmacokinetic-pharmacodynamic (PKPD) dose-finding study by Ahmadzia and colleagues, 30 pregnant women (10 women in each study arm) received 5 mg/kg, 10 mg/kg, or 15 mg/kg doses of tranexamic acid for the prevention of postpartum hemorrhage. Advanced PKPD modeling demonstrated that 600 mg of tranexamic acid was the optimal dose to use in the prevention of postpartum hemorrhage.
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Drospirenone and Estetrol Tablets (Nextstellis)
Nextstellis can be prescribed to women of reproductive potential to prevent pregnancy.