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Long-Term Peripheral Nerve Function Changes in People with Well-Controlled Type 2 Diabetes

The authors conducted a prospective observational study comparing the effect of early diagnosed, well-controlled type 2 diabetes on peripheral nerve function. Overall, they found similar rates of decline in nerve function in people with well-controlled diabetes compared to age- and sex-matched individuals with normal glucose tolerance. Given the similar decline in nerve function, the authors concluded that the course of diabetic sensorimotor neuropathy is influenced primarily by nerve function at the time of diagnosis and age-related physiological decline.

Endocrine Causes of Secondary Hypertension

Primary care providers should maintain a high index of suspicion for endocrine-related secondary hypertension, particularly in patients with resistant hypertension or atypical presentations. Conditions such as pheochromocytoma, primary hyperaldosteronism, and Cushing syndrome are common, yet frequently underdiagnosed causes that, if missed, can lead to rapid end-organ damage. This article emphasizes the need for early recognition and diagnostic vigilance, and equips clinicians with guidance to improve diagnostic accuracy and enhance patient outcomes through targeted treatment.

Does an Elevated Troponin Level Post-Exercise Indicate Occult Coronary Atherosclerosis?

In middle-aged competitive recreational athletes, increases in cardiac troponin levels with exercise competitions were not infrequent. In a subgroup, coronary artery calcium by computed tomography was found in almost two-thirds, but the prevalence and magnitude of calcium was not associated with the exercise troponin response.

Does Lipoprotein(a) Improve the Risk Calculation of the PREVENT Equation?

A pooled cohort from the Multi-Ethnic Study of Atherosclerosis and the United Kingdom Biobank study has shown that, overall, the American Heart Association PREVENT risk scores performed well at predicting atherosclerotic cardiovascular disease risk even in those with high lipoprotein(a) levels, but considering lipoprotein(a) in those with low PREVENT scores may help make therapeutic decisions in these individuals.

Benefits of Nudging in Severe Aortic Stenosis

A single health system study of electronic provider notifications when severe aortic stenosis was discovered on echocardiography showed that referrals for aortic valve replacement significantly increased, especially in women and those > 80 years of age.

Balloon Angioplasty for Chronic Thromboembolic Pulmonary Hypertension

A multinational, prospective registry of balloon pulmonary angioplasty has shown that significant improvement in patients with chronic thromboembolic pulmonary hypertension can be accomplished with few complications and no periprocedural mortality.

Complications with the First Transcatheter Tricuspid Valve: Real-World Analysis

This review of complications seen in real-world practice with the Evoque transcatheter tricuspid valve highlights the need for careful patient selection and operator training with this technology.

Gepotidacin Tablets (Blujepa)

The U.S. Food and Drug Administration has approved gepotidacin, a first-in-class antibacterial medication for the treatment of uncomplicated urinary tract infections. It is the first new class of oral antibiotics approved in nearly 30 years.

Can Hyperemesis Gravidarum Be Prevented with Metformin?

Although differences were not statistically significant, women with pre-conceptional metformin exposure appeared to have lower rates of hyperemesis gravidarum and comparable nausea and vomiting symptom severity, suggesting a potential protective effect that warrants further investigation in larger, adequately powered studies.

What Are Period Pills?

In this national survey of almost 7,000 people aged 15 to 49 years who were assigned female sex at birth, conducted between December 2021 and January 2022, one-quarter of participants (24%; 95% confidence interval [CI], 22%, 25%) stated that they would personally use period pills and about half of the respondents (52%; 95% CI, 50%, 53%) were in favor of the availability of period pills.