Neurology Alert – June 1, 2018
June 1, 2018
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Prediction of Persistent Post-concussion Symptoms After Mild Traumatic Brain Injury
Persistent post-concussion syndrome may last for more than six months, and risk factors include female sex, neck pain, headache, and post-concussive symptoms at two weeks after the injury.
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Intracranial Pressure Changes in Mild Traumatic Brain Injury
After an exhaustive review of the animal and human studies literature regarding mild traumatic brain injury (mTBI), Haider et al. did not reach consistent conclusions regarding evidence for intracranial pressure elevation in human patients who sustain an mTBI.
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What Are the Early Predictors for Post-traumatic Epilepsy After Injury?
Following traumatic brain injury, early (first five days after injury) epileptiform abnormalities on EEG were seen more commonly in patients with subsequent post-traumatic epilepsy (PTE), compared to controls, and were found to be a significant and independent predictor of PTE. The presence of subdural hemorrhage was the only other independent predictor of PTE.
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Longitudinal tau PET as an Outcome Measure for Clinical Trials
tau PET imaging shows progression of brain Alzheimer’s pathology over time and correlates with cognitive impairment better than amyloid PET. In future clinical trials, tau PET can serve as a biomarker for Alzheimer’s disease progression.
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Anti-MAG Antibodies: Clinical and Therapeutic Aspects
Anti-MAG antibody-associated neuropathy may present as many disorders, including small fiber neuropathy, sensorimotor neuropathy, Guillain-Barré-like syndrome, and multifocal motor neuropathy. Rituximab appears to be the best therapeutic option.