– October 1, 2007
October 1, 2007
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Lenalidomide Treatment in Patients with Renal Insufficiency: More Neutropenia Observed
Neutropenia occurs commonly in lenalidomide treated multiple myeloma patients. In this review of a series of newly diagnosed patients, pre-treatment renal dysfunction was clearly associated with increased dose modification-requiring neutropenia. -
New Regimen for Poor Risk AML
A novel regimen is introduced for the treatment of high-risk acute myelogenous leukemia. In a single-institution phase II trial, flavopiridol, a synthetic flavone, in combination with cytosine arabinoside and mitoxantrone induced durable complete remissions in new patients with secondary leukemia and in those with relapsed disease. -
Low Risk of CHF from Imatinib
Imatinib has recently been reported to cause CHF, but the clinical incidence is unclear. -
Combination Chemotherapy for Unknown Primary
Carcinoma of unknown primary remains a management problem without an established approach demonstrated to prolong survival. In a phase II study, the combination of carboplatin, gemcitabine, and capecitabine was shown to be fairly well tolerated and, for certain subsets, effective in producing transient tumor regression. -
More on Breast Cancer in the Elderly
In a national survey conducted in Italy, data from 1085 women 65 years and older with newly diagnosed breast cancer was analyzed with regard to stage at presentation, histological features and treatments provided. -
Pharmacology Watch
Stopping statins, even briefly, after stroke or cardiovascular surgery increases vascular complications according to 3 new studies. -
Clinical Briefs in Primary Care Supplement