Internal Medicine Alert
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Weight Loss Without Bone Loss: Mediterranean Diet and Exercise in Older Women
This systematic review found that, among older women undergoing intentional weight loss, bone density is better preserved with a calorie-restricted Mediterranean diet combined with physical activity, compared to a standard Mediterranean diet alone.
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Patients Hospitalized for Non-Severe COVID-19: No Benefit of CAP Antibiotics
A large population-based, retrospective, cohort study found there was no benefit for antibiotics targeting community-acquired pneumonia in patients hospitalized with non-severe COVID-19. These results provide evidence against antibiotic use in this population.
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Post-Traumatic Headaches: Common and Complicated
The brain’s ability to modulate pain influences the development and persistence of post-traumatic headache (PTH). Functional magnetic resonance imaging (fMRI) studies in people with PTH show higher pain-induced brain activation in specific regions, such as the postcentral gyrus, superior temporal gyrus, and ventral striatum, as compared to healthy controls. Over 16 weeks of observation, progressive normalization in pain-induced brain activation was seen in the PTH group with headache improvement, with persistently elevated activation in the non-improvement PTH group.
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Why Does Colonization Become Active C. difficile?
These authors performed a nested case-control study to identify risk factors for the progression from Clostridioides difficile colonization to active infection in hospitalized persons.
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Avutometinib Capsules and Defactinib Tablets (Avmapki Fakzynja CO-PACK)
The U.S. Food and Drug Administration has granted accelerated approval for a combination of two kinase inhibitors, avutometinib and defactinib, for the treatment of KRAS-mutated recurrent low-grade serous ovarian cancer who have received prior systemic therapy, including a platinum-based regimen.
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Pediatric Tachycardia?
The electrocardiogram in the figure is from a previously healthy 15-year-old boy who reports palpitations and dizziness over the past two weeks. How would you interpret this tachycardia?