Infectious Disease Alert – September 1, 2022

Parechovirus Meningoencephalitis in Infants

Parechovirus A3 is a leading cause of meningoencephalitis in infants.

Ibrexafungerp for Vulvovaginal Candidiasis

The authors of a randomized clinical trial compared one day of oral ibrexafungerp with placebo for women with vulvovaginal candidiasis (VVC). They found ibrexafungerp to be safe and effective, with mild diarrhea the most common adverse event. Ibrexafungerp differs mechanistically from azoles and appears to be a promising new treatment for VVC.

Marburg Virus Outbreak in Ghana — Should We Worry?

An outbreak of Marburg virus disease, an illness resembling Ebola, is occurring in Ghana, only the second such event in West Africa. Will it spread beyond Africa?

Macrolides and Hearing Loss — A Risk for Children?

In a large U.S. population group, use of short-term oral azithromycin was associated with an increased risk of sensorineural hearing loss.

Melioidosis May Be Acquired by Exposure to Contaminated Soil in the Gulf Coast of the United States

Exposure to contaminated soils in the U.S. Gulf Coast is a risk factor for acquiring melioidosis.

Poliovirus in London and New York

Poliovirus is present in wastewater in London and New York and has caused polio in a man in the New York City metropolitan area.

Adeno-Associated Virus 2 May Be the Cause of Unexplained Hepatitis in Children

With next-generation sequencing and real-time polymerase chain reaction, researchers detected adeno-associated virus 2 in the plasma of 9/9 patients and in the liver of 4/4 patients but not in healthy controls, children with adenovirus infection and normal liver function, or children admitted to the hospital with hepatitis of another etiology.

Infectious Disease Alert Updates

Questions in Gonorrhea Management; Ertapenem Non-Inferior to Ceftriaxone in Gonorrhea