Infectious Disease Alert – December 1, 2025
December 1, 2025
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An Oral Vaccine Against Salmonella Paratyphi A Shows Promise
In a Phase IIb controlled human infection model study, the oral live attenuated vaccine CVD 1902 demonstrated 73% efficacy against Salmonella Paratyphi A infection, with a favorable safety profile and robust immunogenicity, supporting advancement toward field trials in endemic populations.
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Imposed Diagnostic Stewardship and Pediatric Blood Cultures
A children’s hospital developed a strategy to restrict indications for ordering blood cultures when supply chain problems led to a shortage of blood culture bottles. Evaluating outcomes, they realized that the imposed diagnostic stewardship preserved resources without harm to patients; they subsequently continued to impose restrictions on ordering blood cultures even when supplies were available.
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COVID-19 Vaccine Receipt Was Associated with Better Clinical Outcomes in U.S. Veterans
An observational study from the Department of Veterans Affairs found that individuals who received the 2024-2025 COVID-19 vaccine and the influenza vaccine on the same day had fewer emergency department visits, COVID-19-associated hospitalizations, and deaths related to COVID-19 compared to a group that only received the influenza vaccine.
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Comprehensive Data Analysis Validates the Effectiveness and Safety of COVID-19, RSV, and Influenza Vaccination
Respiratory syncytial virus, influenza, and COVID-19 vaccines are safe and effective.
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Cephalexin Beat Cefdinir for Treating Uncomplicated UTI in Women
Cefdinir was inferior to cephalexin in the treatment of uncomplicated urinary tract infections in women due to a high rate of early recurrence.
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Infectious Disease Updates
Lyme Disease; Pregnant Women Must Be Screened for Syphilis; Pacific Coast Tick Fever