Articles Tagged With:
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IRB Experts Offer Advice for Changing Research Landscape
It is clear that clinical trials now exist in a different world from what researchers, IRBs, and sponsors experienced in 2019. The key challenges are how to restart clinical trials, how to return to in-person visits, and how to manage the growing number of studies related to COVID-19.
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Intermittent Fasting: A Faster Way to a Longer Life?
Intermittent fasting, which once was strictly in the purview of religion and health fads, has undergone a rapid increase in scientific interest. Studies now demonstrate the positive impact that various methods of intermittent fasting can have on overall health.
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ACS Prepares Surgeons for Resuming Elective Procedures
The COVID-19 pandemic forced many facilities to press pause on regular operations. Now, some are ready to chart a course back toward some sense of normalcy.
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Infectious Disease Alert Updates
Complications of Typhoid Fever; Do I Smell a Rat? Or Is the Rat Smelling Me? Cloth Masks — Just for Looks?
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Lefamulin: Formulary Considerations
The Food and Drug Administration (FDA) recently approved lefamulin for the treatment of adults with community-acquired bacterial pneumonia (CABP).
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Antibiotic Therapy to Reduce the Incidence of Ventilator-Associated Pneumonia After Cardiac Arrest
In this prospective, randomized trial, intravenous amoxicillin-clavulanate (dosed three times daily and given for two days) administered to patients admitted with out-of-hospital cardiac arrest due to a shockable rhythm reduced the incidence of early ventilator-associated pneumonia.
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Carbapenem-Resistant Enterobacterales (CRE) in the USA — A Molecular and Clinical Analysis
Patient mortality rates were high among patients from whom carbapenem-resistant Enterobacterales (CRE) were cultured, regardless of whether the organism was causing infection or was a only a colonizer. In addition, mortality was similar regardless of whether a carbapenemase gene was present. Finally, not all “CRE” were truly CRE.
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Clostridioides difficile: Risk Factors for Disease
Approximately one-tenth of asymptomatic patients with Clostridioides difficile colonization went on to develop disease. A wide range of antibiotic exposures represent a significant risk.
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Inappropriately Broad Empiric Antibiotics Are Associated with Higher Mortality in Community-Onset Sepsis
A retrospective cohort study found that broad-spectrum antibiotics were unnecessarily prescribed to patients with community-onset sepsis and was associated with worse outcomes and higher mortality.
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Biologic Warfare: A Game-Changer in the Battle Against Malaria?
A non-pathogenic microsporidian organism can infect Anopheles mosquitoes and block the transmission of malaria parasites, without negatively altering the life of the mosquito. This organism potentially could be used for widespread malaria control.