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The Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT) showed that implantation of a cardiac-resynchronization therapy with a defibrillator (CRT-D) in patients with left bundle-branch block (LBBB), Class I or II congestive heart failure (CHF), and an ejection fraction < 30% was associated with a significant reduction in heart-failure events over 2.4 years.
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Most current guidelines recommend exercise electrocardiographic (ECG) testing for suspected coronary artery disease (CAD) in patients who can exercise and have a normal resting ECG.
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In patients with stable coronary artery disease and atrial fibrillation (AF) on oral anticoagulants, adding antiplatelet agents is common and recommended in guidelines, especially during the first year after an acute coronary event or revascularization.
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The mortality benefit to percutaneous coronary intervention (PCI) is unquestioned when it comes to ST-elevation myocardial infarction (STEMI).
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In patients with severe degenerative mitral regurgitation (MR), surgery is clearly recommended in the presence of any symptoms.
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In a prospective study of 35 patients with newly diagnosed idiopathic intracranial hypertension confirmed by diagnostic lumbar puncture and treated with standard medication regimens, 43% of patients had excellent headache outcome at 12 months, with the major improvement seen within the first month of diagnosis.
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Unlike other neuromuscular disorders, physical exercise does not appear to worsen weakness in patients with Charcot-Marie-Tooth disease.
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At least 30% of strokes in China are caused by intracerebral hemorrhage, compared with approximately 10-15% in North America.
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Targeted high-coverage sequencing for causal somatic mutations in patients with cortical malformations is more sensitive than traditional Sanger and whole-exome sequencing.
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The risk of varicella-zoster virus infections in patients treated with fingolimod is slightly higher than placebo, but is overall quite low.
