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  • Ethical Approaches for End-of-Life Communication with Non-English-Speaking ICU Patients

    When caring for non-English-language-speaking intensive care unit patients, clinicians face all the same ethical issues as they do with any other patient, and some additional ones when cases involve patients who speak rarer languages.

  • Emotional Effect of Clinical Ethics Work Often Goes Unrecognized

    There is a great deal of focus on the emotional well-being of nurses and physicians, but the effects of clinical ethics work on ethicists are largely undiscussed. Anna Goff, PhD, HEC-C, colleagues interviewed 34 clinical ethicists in 2023 to learn the effect of their professional responsibilities and how coping mechanisms and organizational structures can help.

  • Systolic Blood Pressure Targets in Octogenarians

    An analysis of a U.S. national database of patients 80 years of age or older taking antihypertensive agents was analyzed to determine the optimal systolic blood pressure associated with the lowest cardiovascular mortality and found that the ideal target was < 130 mmHg.

  • Direct Oral Anticoagulants vs. Warfarin for Left Ventricular Thrombus

    A small pilot randomized controlled trial, plus a meta-analysis including four other randomized controlled trials, of direct oral anticoagulants compared to warfarin for the treatment of left ventricular thrombus after ST-elevation myocardial infarction has shown that there were no significant differences in the two regimens regarding thrombus resolution and major bleeding events at three-month follow-up.

  • The Cause of the ‘Burning?’

    The electrocardiogram (ECG) in the figure is from a man with a new and severe “burning” chest discomfort. On seeing this ECG, the paramedic team requested activating the cath lab. Would you have done the same?

  • Use of Coronary Calcium Score in Familial Coronary Artery Disease

    A randomized trial of computed tomography (CT) coronary artery calcium score augmented management vs. usual care of primary prevention patients at moderate risk of a coronary event and with a family history of premature coronary events has shown that, after three years of follow-up, the calcium score group had lower low-density lipoprotein cholesterol levels and smaller total plaque volumes by CT angiography.

  • Aztreonam and Avibactam for Injection (Emblaveo)

    The U.S. Food and Drug Administration has approved a new combination antibiotic for the treatment of complicated intra-abdominal infections where there are limited or no alternative options.

  • Death Due to the ‘No Name’ Virus in Santa Fe

    On Feb. 26, 2025, it was announced that the bodies of actor Gene Hackman and his wife and caregiver Betsy Arakawa had been found in their Santa Fe, NM, home

  • New Indications for Aortic Valve Replacement in Chronic Aortic Regurgitation

    A retrospective observational study of asymptomatic patients with isolated moderate to severe or severe aortic valve regurgitation by echocardiography has shown that left ventricular (LV) ejection fraction (EF) < 60%, LV end systolic volume index > 45 mL/m², or global longitudinal strain less than -15% is associated with all-cause mortality, but mortality is highest when current guideline recommendations are present. This suggests that there is a survival penalty with the sole use of the current guidelines.

  • Bacterial Vaginosis: Treat the Man, Too

    In a randomized trial, treatment of the regular male partner with oral and topical agents was strongly associated with a reduced risk of recurrence of bacterial vaginosis in the female partner.