Articles Tagged With:
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Canakinumab Injection (Ilaris)
Canakinumab can be prescribed to adults with gout in whom nonsteroidal anti-inflammatory drugs and colchicine are contraindicated, are not tolerated, or do not provide an adequate response, and in whom repeated courses of corticosteroids are not appropriate.
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An RNA Shot for Hypertension?
One dose of a new RNA-based drug administered by subcutaneous injection, which blocks hepatic angiotensinogen production, resulted in sustained reductions in blood pressure in patients with hypertension for up to 24 weeks without any serious adverse effects.
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Is the Combination of a GLP-1 Agonist and a SGLT2 Inhibitor Safe?
An analysis of the Harmony Outcomes study and a meta-analysis combining it with the AMPLITUDE-O study of the addition of a glucagon-like peptide 1 receptor agonist (GLP-1 RA) in a subgroup of type 2 diabetes patients on baseline sodium-glucose cotransporter-2 (SGLT2) inhibitor therapy has shown that major adverse cardiovascular events are reduced by GLP-1 RA, regardless of baseline SGLT2 use, and there was no difference in serious adverse events.
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Treating Preclinical Alzheimer’s Disease
After studying an anti-amyloid antibody, solanezumab, researchers reported there was no benefit in reducing the likelihood of progression of cognitive impairment in patients with positive amyloid PET scans who started the trial cognitively unimpaired, compared to placebo.
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Turmeric (Curcumin) Helps Patients with Dyspepsia and Acid Reflux
In a randomized, controlled trial, curcumin demonstrated comparable efficacy to omeprazole in treating dyspepsia and acid reflux.
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Tachycardia in the Emergency Department: Part II
This issue completes the two-part series on tachycardia. This issue will finish the discussion of additional causes of tachycardia, address management, and conclude by covering some challenging issues with this arrhythmia.
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Chronic Obstructive Pulmonary Disease Update for Primary Care Providers
The Global Initiative for Chronic Obstructive Lung Disease 2023 report defines chronic obstructive pulmonary disease (COPD) as a heterogeneous lung condition characterized by chronic respiratory symptoms (dyspnea, cough, sputum production, and/or exacerbations) caused by abnormalities of the airways (bronchitis, bronchiolitis) and/or alveoli (emphysema) that result in persistent, often progressive, airflow obstruction. COPD was the fourth leading cause of death in the United States in 2018 and is estimated to be responsible for 3 million deaths annually around the world, with expected increases to 5.4 million annual deaths from COPD and related conditions by 2060.
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Pediatric Hernias: Diagnosis and Management
Hernias are a common condition encountered by emergency providers and can be overlooked if the genitourinary system is not included in the evaluation of every child with vomiting or abdominal pain. Incarcerated hernias that are not identified in a timely fashion can have devastating consequences for a child. The authors provide an anatomical review, along with diagnostic and therapeutic approaches to pediatric hernias.
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Lung Ultrasound Score Can Adequately Diagnose Acute Respiratory Distress Syndrome
In this prospective, observational study, lung ultrasound showed comparable diagnostic performance to standard diagnostics but better accuracy.
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Studying Patients at High Risk for Death in the ICU Can Give Them a Voice and Help Clinicians Understand Their Concerns
Using a multiple-source approach, this study showed that when given a voice, patients at high risk of dying in the intensive care unit express variable logistical, spiritual, physical, psychological, and existential concerns that clinicians should consider and address.