Articles Tagged With:
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Searching for a Neuroprotective Agent in Celery Seed Oil
A Phase III double-blind, placebo-controlled, randomized, controlled trial suggests that early administration of DL-3-n-butylphthalide, when given adjunctively to thrombolysis or endovascular therapy, improves functional outcomes in patients with acute ischemic stroke. Statistically significant results of well-designed analyses are tantalizing, but confidence in the findings is tempered by a lack of generalizability, an unclear mechanism of action, and trial design irregularities.
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Can Internet Use Prevent Dementia?
In an ongoing longitudinal survey of a nationally representative sample of dementia-free adults age 50 to 64.9 years, regular internet users experienced approximately half the risk of dementia compared with non-regular users.
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Examining the Effect of Physical Activity and Depressive Symptoms in Adolescents
In a robust meta-analysis of 21 studies, physical activity interventions showed a significant short-term benefit for children and adolescents with depressive symptoms, particularly in those aged 13 years and older and in participants with a diagnosis of depression.
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Computer-Interpreted ECGs Sometimes Miss Acute Coronary Occlusion
Emergency physicians can shield against risk by viewing ECGs of chest pain patients immediately to identify subtle signs of acute coronary occlusion.
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Acute Vertigo Caused by Herpes Zoster Oticus
Herpes zoster oticus (HZO) and vestibular neuritis (VN) can be difficult to distinguish, but treatments may be different. Magnetic resonance imaging may help by showing inflammatory lesions in the vestibular nuclei or the proximal portions of the eighth nerves in HZO, but not VN.
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Autoimmune Encephalitis After Herpes Simplex Virus Encephalitis
A recent study showed that about 25% of patients with herpes simplex encephalitis develop neurological symptoms three to six weeks after the infection, pointing toward an autoimmune process with different neurological and psychiatric symptoms. Anti-neuronal antibodies, such as anti-N-methyl-D-aspartate receptor antibodies, have been found in this post-viral autoimmune encephalitis presentation.
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Treatable Causes of Rapidly Progressive Dementias
Many cases of rapidly progressive dementia are caused by prion diseases and have no effective treatments. But, with the greater awareness of the presentation for autoimmune encephalitis, these disorders make up an increasing percentage of presenting cases and can be aggressively and successfully treated. The STAM3P score helps to identify potentially treatable cases of this disorder.
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Early Onset Post-Radiation Neuropathy
Biopsy studies of early onset neuropathies seen after radiation therapy consistently show evidence of microvasculitis and other signs of inflammation. Early and rapid treatment with anti-inflammatory medications may be effective in stopping the progression and speeding up recovery.
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Hepatitis E and Neuropathy
In this prospective case-control study of patents with neuralgic amyotrophy, Guillain-Barré syndrome, and Bell’s palsy, an association with acute hepatitis E infection was demonstrated only with neuralgic amyotrophy.
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Necessity and Reinvention: APIC Tries to Hire, Retain IPs
As a generation of infection preventionists (IPs) near career end, it is well to remember that many of them tell a similar story of how they got into the profession. Often, they were working some other clinical job and an opening or temporary need came up in the infection control department. To paraphrase what Hospital Infection Control & Prevention has reported time and again from new IPs to long-established leaders in the field, “I just fell into it and I loved it. I found it fascinating.”