Articles Tagged With:
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Does Selective Decontamination of the Digestive Tract Reduce In-Hospital Mortality in Critically Ill Adults?
The SuDDICU randomized controlled trial of Australian patients found that selective decontamination of the digestive tract (SDD) did not significantly decrease in-hospital mortality, although the confidence interval around the effect estimate includes a clinically important benefit. In a separate systematic review and meta-analysis that included 32 randomized trials and 24,389 participants, SDD was associated with reduced hospital mortality compared with standard care.
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Does Surviving an ECMO Stay Put Patients at Greater Risk for Mental Health Problems?
Survivors of extracorporeal membrane oxygenation (ECMO) have a modest increase in risk of new mental health diagnoses after discharge compared with intensive care unit survivors who do not undergo ECMO.
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Patients with Solid Tumors Admitted with Septic Shock: Outcomes and Mortality Predictors
The presence of metastatic disease, respiratory failure, elevated lactate levels, and poor prior performance scores were independent predictors of mortality in patients with solid tumors admitted with septic shock.
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Infectious Disease Alert Updates
Loss of Monoclonal Therapy for COVID-19; Cost-Savings of Outpatient Antimicrobial Therapy
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The Dental Procedure-Infective Endocarditis Link Controversy Continues
Infective endocarditis was more common with dental surgery or tooth extractions in the preceding four weeks in high-risk patients. Researchers abrogated this risk with antibiotic prophylaxis before the procedure.
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Vaccination Against Mpox: Does it Work? Is it Safe?
Vaccination, either subcutaneously or intradermally, with the non-replicating JYNNEOS vaccine is safe and effective.
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When More Is Not Better: Treatment of Prosthetic Valve Endocarditis Due to Staphylococci
Clear evidence of benefit from adjunctive administration a β-lactam and/or a glycopeptide in the treatment of prosthetic valve endocarditis due to staphylococci is lacking. Current guidelines need to be reassessed.
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Resistance of SARS-CoV-2 Variants to Monoclonal Antibodies
Prevalent SARS-CoV-2 variants are increasingly resistant to therapeutic and prophylactic monoclonal antibodies but remain susceptible to Paxlovid, remdesivir, and molnupiravir.
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Salmonella Gastroenteritis — The Risk of a Rapid, Accurate Diagnosis
Availability of molecular testing panel results that were positive for Salmonella in children led to increased hospital admissions, increased subsequent microbiologic testing, and increased antibiotic use — all without benefit to patients.
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Statin Use with Daptomycin: Do We Finally Have a Definitive Answer?
A meta-analysis on published literature and a disproportionality analysis using Food and Drug Administration data found that statin use was associated with the occurrence of daptomycin-induced musculoskeletal adverse events. In most cases, statin use should be discontinued while patients are on daptomycin.