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  • Surgical Approaches to Decompression in Degenerative Lumbar Spondylolisthesis

    For patients with symptomatic lumbar stenosis and single-level spondylolisthesis who were refractory to conservative treatment, there was no significant difference between outcomes in those who underwent decompression surgery with instrumented fusion vs. decompression surgery without fusion.

  • Homelessness and COVID-19

    Extra screening in care for homeless persons can help solve many problems, including the administration of COVID-19 vaccination to this vulnerable population.

  • Slow, Steady, and Synchronized Wins the Race

    In patients with atrial fibrillation and heart failure, definitive rate control via atrioventricular junction ablation and biventricular pacing resulted in a significant reduction in all-cause mortality vs. pharmacologic rate control.

  • Resistance Erodes Standard Treatment for Pneumonia

    These data suggest community-acquired pneumonia CAP therapy may no longer be relevant for many patients with CAP, and the required use of the current CAP bundle with limited antibacterial therapy choices should be re-assessed.

  • Pediatric Tuberculosis

    Mycobacterium tuberculosis (MTB) is a significant chal­lenge to children's health. Barriers exist at multiple levels of the care system for MTB. Early recognition and involvement of MTB specialists is critical to facilitate the best outcome for pediatric patients. The authors provide a thorough review of the current standards for care of these challenging patients.

  • Overdiagnosis of Chronic Kidney Disease in the Elderly

    Older patients experience a physiological decline in estimated glomerular filtration rate. However, if the same levels are used to define chronic kidney disease for all adults, older patients not at a higher risk for kidney failure might still be classified with the disease.

  • Are Female Surgeons at Higher Risk for Infertility and Pregnancy Complications?

    In this cross-sectional national survey of 850 surgeons, compared to the partners of male surgeons, female surgeons were more likely to have fewer children (1.8 vs. 2.3) and to delay having children because of surgical training (65% vs. 44%). Female surgeons also were more likely to use assisted reproductive technology (25% vs. 17%).

  • Zuranolone Trial Shows Early Promise as an Oral Neuroactive Steroid for the Treatment of Postpartum Depression

    Zuranolone was approved by the Food and Drug Administration for the treatment of postpartum depression (PPD) in March 2019. One potential factor identified in PPD etiology is the dramatic perinatal changes in circulating levels of allopregnanolone, a neuroactive steroid with gamma-aminobutyric acid type A (GABAA) receptor positive allosteric modulator properties. In brain regions associated with emotion and self-perception, neural network connectivity supported by GABAergic signaling is positively correlated with plasma allopregnanolone concentrations in individuals with PPD vs. healthy postpartum female individuals.

  • Is Prenatal Screening for GBS Cost-Effective in the United States?

    In this cost-effectiveness study, screening for group B streptococcus (GBS) at 36 0/7 to 37 6/7 weeks, with rescreening (if GBS results are negative after five weeks of initial screening), is the most cost-effective strategy.

  • Barriers to Abortion Care and Self-Managed Abortion

    In this prospective national study among people searching for abortion care online, 28% of respondents reported attempting self-managed abortion. Respondents living farther from an abortion facility and facing barriers to care were more likely to attempt self-managed abortion.