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In a trial comparing chemotherapy alone to chemotherapy plus bevacizumab in the treatment of patients with platinium-resistant ovarian cancer, the combination resulted in improved response rates and progression-free survival (PFS) and without a high rate of added toxicity. Whether bevacizumab alone would provide comparable improvements was not assessed but remains an important question for future trials.
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In an international, randomized, non-inferiority trial, bendamustine-rituximab proved comparable in overall response rate when compared with R-CHOP or R-CVP in the management of indolent NHL and mantle cell lymphoma. Progression free and overall survival comparisons remain to be determined. Notably, toxicity profiles were significantly different, with higher rates of reported nausea and vomiting with BR and neuropathy and alopecia with R-CHOP/R-CVP.
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Breast cancer survivors participating in a 12-week yoga program reported decreased fatigue, increased vitality, and improved sleep on multiple scoring systems, but no impact on depressive symptoms. Increased time spent doing yoga led to greater improvements in inflammation, mood, and fatigue.
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What is the Best Treatment for Cerebral Cavernous Malformations?
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In this prospective study, the authors use brain imaging criteria to determine whether acute febrile status results in acute hippocampal injury and potentially chronic hippocampal sclerosis.
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A new case-control study finds that increased levels of dichlorodiphenyldichloroethylene (DDE), which is the metabolite of the pesticide dichlorodiphenyltrichloroethane (DDT), are associated with an increased risk for Alzheimer's disease.
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Trochlear headaches should be considered in patients with new onset, constant, unilateral eye pain, especially when the pain is aggravated by eye movement.
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Most patients who develop cryoglobulinemia associated with hepatitis C infection will develop symptoms and signs of a symmetric, distal sensory neuropathy.
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“I can’t afford that test,” “Don’t bother giving me an appointment for a specialist because my insurance won’t cover it,” “I can’t pay for that medication.” When an emergency department (ED) patient makes statements such as this, the emergency physician (EP) is often faced with few or no financial assistance options for the patient to achieve the recommended course of care.
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In the April 2013 case of Missouri v. McNeely, the Supreme Court ruled that police must generally obtain a warrant before subjecting a drunk-driving suspect to a blood test.
