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Regionalized health care systems exist for trauma and neonatal care and efforts are underway to institute similar systems for high-risk surgeries, three fields in which there is a positive relationship between the volume of cases handled and patient outcomes.
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This study sought to determine whether the occurrence of in-hospital cardiac arrest at night and on weekends was associated with worse outcomes as compared with arrests during day/evening shifts and on weekdays.
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In This Issue: FDA drug approval to change? Urinary incontinence in women; how metabolism of certain drugs can be predicted by genetic analysis; bowel preps may compromise renal function especially in the elderly according to a new study; FDA Actions.
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In a retrospective analysis of 740 patients with stage I-III breast cancer, preoperative serum levels of CA 15-3 and CEA were both shown to relate to important clinical outcomes, including disease-free and overall survival.
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In a pilot study of ovarian cancer patients treated with sorafenib and bevacizumab, CA125 concentrations were shown to not correspond with imaging analyses in the assessment of treatment response. Thus, caution is raised about using this tumor marker alone in the assessment of treatment outcomes for patients treated with newer, molecularly-targeted therapies.
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In a randomized, prospective trial, anemic chemotherapy-receiving patients received either darbepoetin alone or darbepoetin with intravenous ferric gluconate. The group that received the added ferric gluconate had a significantly higher rate of achieving objective criteria for anemia improvement. The iron infusions were associated with no observed toxicity.
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Hypereosinophilic syndrome (HES) is a spectrum of diseases where a primary cause of eosinophilia can not be identified.
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For premenopausal ER+ breast cancer patients receiving CMF chemotherapy in an adjuvant setting, the presence of anemia during treatment was found to be a significant risk factor for the development of local recurrence.
