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In a large series of acute myelogenous leukemia patients, elevated serum beta-2 microglobulin was found to be an independent negative prognostic factor with regard to overall survival, but was significant only for those over the age of 60 years.
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Prophylactic cranial radiation (PCI) has been shown to reduce the incidence of CNS metastases and prolong survival for patients presenting with limited-stage small cell lung cancer (SCLC). However, concern that such treatment results in cognitive decline has tempered enthusiasm, but this claim has not been satisfactorily addressed.
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Immune thrombocytopenia is a problematic but poorly characterized complication of chronic lymphocytic leukemia. The authors propose a definition for immune thrombocytopenia in CLL that included a 50% drop in platelet count and adequate marrow megakaryocytes in the absence of chemotherapy or other causes.
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A prior use of oral contraceptives has been known to have an inhibitory effect on ovarian cancer development.
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Stop smoking drug Chantix rates stronger warning from FDA; Type 2 diabetes surgery on the way?; Vytorin study inconclusive; Influenza A virus found resistant to Tamiflu; FDA actions.
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Left main coronary artery stenosis is one of the primary indications for coronary artery bypass graft surgery (CABG). Recently, a number of non-randomized studies and registries have suggested that stenting, using current techniques and devices, may be a feasible alternative to CABG.
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Patients with a positive CT scan for coronary calcium often have a stress test. Askew and colleagues from the Mayo Clinic asked whether such patients should undergo repeat stress testing if the first one is negative or low risk?
