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Acute lymphocytic leukemia (ALL) in the elderly is not common, but as in younger adults, a subset will be Philadelphia chromosome postitive (Ph+). In young patients with Ph+ ALL, the addition of imatinib has been shown to be effective in enhancing complete response rates and relapse-free survival.
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A review of twenty AML patients who were treated with azacitidine demonstrated a response rate of 60% and for those that responded, a median survival of 15+ months.
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ITP is usually a chronic condition in adults resulting from both platelet destruction and impaired production. This study summarizes the early phase experience in two trials for chronic refractory ITP of AMG 531, a novel thrombopoiesis stimulating protein.
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The findings of the current study suggest that the extent of lymph node resection improves the survival of women with intermediate/high-risk endometrioid uterine cancer.
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The question of the role for systemic therapy in addition to surgical resection of liver metastases was addressed by Portier and colleagues from France.
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In response to several high-profile drug misadventures including the rofecoxib (Vioxx®) withdrawal from the market, the FDA's Center for Drug Evaluation and Research (CDER) asked the Institute of Medicine (IOM) to assess the drug safety system in the United States.
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Collaborative model works in Knoxville RRT initiative
