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  • Bacterial Vaginosis: Treat the Man, Too

    In a randomized trial, treatment of the regular male partner with oral and topical agents was strongly associated with a reduced risk of recurrence of bacterial vaginosis in the female partner.

  • Clinical Consequences of Alzheimer’s and Lewy Body Co-Pathologies

    This large study of patients with cognitive impairment-assessed cerebrospinal fluid biomarkers, positron emission tomography imaging, and cognitive tests showed that those with evidence of both Alzheimer’s and Lewy body pathologies had greater cognitive dysfunction and faster progression than those with either pathology alone.

  • Routine Use of Cerebral Embolic Protection Experiences a Resounding Blow in BHF PROTECT-TAVI

    In this randomized, multicenter trial involving more than 7,600 patients undergoing transcatheter aortic valve replacement, routine use of a cerebral embolic protection device did not reduce the incidence of early post-procedure stroke.

  • Cardiovascular Risk with mRNA COVID Vaccines

    A large, nationwide population study in Sweden of the risk of adverse cardiovascular events after messenger ribonucleic acid (mRNA) COVID-19 vaccinations has shown that, except for rare cases of myopericarditis, severe cardiovascular events, such as myocardial infarction, heart failure, and stroke, are reduced, probably because of the prevention of COVID infection.

  • Measles Vaccination in Adults in 2025

    The Centers for Disease Control and Prevention has updated measles vaccination recommendations.

  • Obesity in Pregnancy

    Obesity in pregnancy can be attributed to multiple factors that include genetic predispositions, lifestyle factors (such as diet and physical activity), and socioeconomic conditions. Over the last two decades, there has been a significant rise in obesity rates among pregnant women, particularly with a notable 33% increase from 2001 to 2018 in women aged 20 to 39 years.

  • Actinomycin-D Treatment for Preventing Post-Molar Gestational Trophoblastic Neoplasia

    This 28-year retrospective cohort study demonstrated that administration of a single 1.25 mg/m2 intravenous dose of actinomycin-D at the time of uterine evacuation for patients with high-risk complete hydatidiform molar pregnancies was associated with a significantly lower rate of post-molar gestational trophoblastic neoplasia (19% vs. 40%, P < 0.001) and a 52% reduction in relative risk (RR; RR = 0.48; 95% confidence interval, 0.35-0.66) in the development of post-molar gestational trophoblastic neoplasia.

  • What Hormonal Side Effects Should New Users of the Levonorgestrel 52-mg IUD Expect?

    This secondary analysis compares the incidence of hormone-related side effects of the levonorgestrel 52-mg intrauterine device (IUD) between users who previously were using combined hormone contraceptives vs. nonhormonal contraceptives to understand which side effects can be directly attributed to the IUD and which are more likely secondary to discontinuation of combined hormonal contraceptives.

  • Are Male Partners the Key to Preventing Recurrent Bacterial Vaginosis?

    In this open label, randomized controlled trial, couples in monogamous relationships whose female partner was diagnosed with bacterial vaginosis were randomized to treatment of the female partner only or to treatment of the female partner plus the male partner. After 150 couples had completed the 12-week follow-up period, recurrence of bacterial vaginosis occurred in 24 of 69 women (35%) in the partner-treatment group and in 43 of 68 women (63%) in the control group, indicating an absolute risk difference of -2.6 recurrences per person-year (95% confidence interval, -4.0 to -1.2; P < 0.001).

  • Mass Casualty Incidents

    Mass casualty incidents are frightening and challenging for both victims and the healthcare professionals who must provide the highest level of care to the most individuals possible, often in uncertain environments. The authors review critical aspects of mass casualty incidents and the latest evidence regarding optimal care and management for patients and staff.