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Although gemcitabine has been proven to be of value in the treatment of advanced pancreatic cancer, remission rates remain low and survival is measured in weeks to months. Swiss investigators report the results from a phase I/II study of combined gemcitabine/capecitabine treatment.
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Taylor and associates report a case of Hashimoto encephalopathy in an adolescent girl with a 9-month history of what was initially diagnosed as chronic fatigue syndrome.
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Benign hyperckemia may be defined as serum elevation of creatine kinase (CK) in an asymptomatic patient or in a patient with nonspecific symptoms, including muscle pain, fatigue, cramps, stiffness, normal neurological examination, and normal or nondiagnostic electrodiagnostic (nerve conduction studies and electromyography) studies.
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Vigabatrin (VGB) is an antiepileptic drug (AED) whose putative mechanism of action is to increase inhibitory tone in the brain by blocking the metabolism of gamma-amino butyric acid (GABA) by irreversibly binding to GABA transaminase.
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HMG-CoA reductase inhibitors (statins) are known to reduce the risk of myocardial infarction and stroke. Statins are effective not only as cholesterol lowering agents but also have beneficial effects on endothelial cell function, as well as antithrombotic and anti-inflammatory effects.
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Mutations in a-synuclein and parkin have been described in families with Parkinsons disease, and both gene products are involved in the function of the proteosome, a major pathway for degradation of proteins within the cell.
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Almost all patients with diabetes eventually develop neuropathy. New therapeutic options for the control of painful diabetic neuropathy are constantly being investigated.
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This population report investigated the prevalence of gluten sensitivity amongst a large cohort of patients with both sporadic and familial ataxia.
