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In a European multicenter trial of interferon alfa with or without bevacizumab for treatment of metastatic renal carcinoma, response rate and progression free survival was superior for those receiving the combination. Future trials, particularly those intending to measure long-term survival will need to also include the newly available tyrosine kinase inhibitors.
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Two recent reports examining NCI-SEER registry data demonstrate improved overall survival when external beam radiation therapy is applied in an adjuvant setting for those with pancreatic cancer.
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Statin drugs have been increasingly used for management of hypercholesterolemia. Preclinical studies indicated an antiproliferative effect in vitro and in rodent models of breast cancer. The current report is one of several that indicate a lack of evidence for reduction in breast cancer risk among statin users. However, the overall use of drugs in this class in the study cohort (7%) and the relatively short duration of use (approximately 4 years) suggest that the question is not completely resolved.
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A randomized multicenter trial conducted almost a decade ago and reported in 2004 showed docetaxel plus prednisone to be superior to mitoxantrone plus prednisone for patients with hormone refractory prostate cancer.
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Rosiglitazone (Avandia) implicated in yet another study; Prilosec and Nexium not associated with cardiac events; Anastrozole (Arimidex) shown more effective than tamoxifen for treatment of early-stage breast cancer; antibiotics show no effect on sinusitis; FDA actions.
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Victims of environmental hypo- or hyperthermia may present seasonally and the number of patients any given practitioner will treat in a year may vary geographically, but no region of the country is immune to either presentation.
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