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Two definite (culture-confirmed), and one probable, cases of K. kingae invasive disease were reported in Minnesota in October 2003, among children attending the same toddler classroom of a childcare center.
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Musher and colleagues followed 207 patients with C. difficile colitis treated with appropriate (at least 1.5 gm/day) doses of metronidazole for at least 7 days. All patients had a positive stool ELISA assay for C. difficile toxin.
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Saccharomyces boulardii (recently recognized as a strain of S. cerevisiae rather than a distinct species) is widely used as a probiotic for the treatment of diarrhea and for the prevention and treatment of C. difficile-associated colitis.
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The FDA has recently approved daptomycin for use in skin and skin-structure infections, but this antibiotic failed the test of non-inferiority in a trial of severe community-acquired pneumonia.
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The FDA has issued a public Health Advisory regarding the identification of 4 cases of toxic shock following medical abortion with Mifepristone (formerly RU-486) and intravaginal misoprostol in the United States.
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Promising New Weight Loss Drug?; Treating Shift-Work Disorder; Another Flu Vaccine Shortage?; FDA Actions
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As a major cause of traumatic death and disability, head injuries require timely diagnosis and management. Because survivors of serious head injuries often have varying degrees of permanent disability, head injury litigation is not uncommon. Furthermore, epidural hematomas may present subtly and progress rapidly toward serious brain injury and death.
