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Infants younger than 28 days are challenging to the emergency department physician, who must be familiar with the normal variants and the subtle findings that may indicate a more serious underlying problem. The amazing physiologic changes that the newborn accomplishes following delivery may precipitate disaster if an underlying congenital problem exists. The astute ED physician is also familiar with particular high-risk times when critical diseases may present, such as cyanotic congenital heart disease, and has a heightened suspicion for these disease processes. This article provides a comprehensive overview of critical diseases that may present in the newborn period and strategies for their early detection and appropriate management.
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Although we have recently enjoyed the FDA approval of two agents for treatment of diabetic peripheral neuropathic pain (duloxetine [Cymbalta], pregabalin [Lyrica]), as yet we have no treatment for diabetic peripheral neuropathy (DPN) itself.
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In 1985 5.6% of pregnant patients were 35 years of age or older, and in 2002 that figure rose to 12.5%. It is estimated that last year 20% of the pregnant population was older than 34 years of age.
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Is Holding NSAIDs Prior to Surgery Rational?; Low-Dose Aspirin: Men vs Women; FDA Actions
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The rationale for this study is interesting. As the trial investigators point out, oxidative injury has been implicated as a key mechanism, leading to atherosclerotic cardiovascular disease and cancer.
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Given the widely variant survival characteristics of women with advanced ovarian cancer, discrete quantifiable differences in tumor biology must exist. Heretofore, accurate characterization has been elusive.
