Internal Medicine Alert – May 15, 2024

Fat May Be the Healthiest Part of Dairy

There are numerous health benefits of dairy fat intake and dairy fat lacks the problems associated with dairy sugar and proteins.

Meningococcal Disease Is on the Rise

The number of cases of infection with Neisseria meningitidis is increasing in the United States. The majority of presentations are with bacteremia; meningitis is infrequent.

Better Outcomes for Acute Stroke Patients Who Arrive Rapidly at Endovascular-Capable Centers

The SELECT2 trial was structured to identify which patients with large ischemic strokes would benefit from endovascular thrombectomy and analyzed the effect of direct arrival at a thrombectomy-capable center compared to transfer from a primary stroke center.

Timing of Biomarker Changes in Alzheimer’s Disease

In a longitudinal multicenter, nested case-control study of cognitive normal participants from China, the time courses of key Alzheimer’s disease biomarkers were identified during the 20 years preceding clinical diagnosis of sporadic Alzheimer’s disease.

Comparing Early vs. Late-Onset MS

A recent retrospective study, combining data from a United Kingdom patient registry with a United Kingdom neuropathology tissue bank, showed that late-onset multiple sclerosis (MS), referring to disease onset after age 50 years, is linked with increased disability and quicker progression compared to MS onset at a younger age, and has distinct pathological features.

Cefepime and Enmetazobactam Injection (Exblifep)

The U.S. Food and Drug Administration has approved the combination of cefepime and enmetazobactam (FPE) for the treatment of complicated urinary tract infections. Cefepime-enmetazobactam was granted a priority review and a five-year marketing exclusivity as part of the Generating Antibiotic Incentive Now (GAIN) Act incentivizing development of new anti-infectives. FPE is distributed by Allecra Therapeutics SAS as Exblifep.

Which Is the Key Lead?

The patient whose ECG appears in the figure is a middle-aged man who presented to the emergency department with new chest pain. Should the cath lab be activated?