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Prophylactic cranial radiation (PCI) has been shown to reduce the incidence of CNS metastases and prolong survival for patients presenting with limited-stage small cell lung cancer (SCLC). However, concern that such treatment results in cognitive decline has tempered enthusiasm, but this claim has not been satisfactorily addressed.
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Immune thrombocytopenia is a problematic but poorly characterized complication of chronic lymphocytic leukemia. The authors propose a definition for immune thrombocytopenia in CLL that included a 50% drop in platelet count and adequate marrow megakaryocytes in the absence of chemotherapy or other causes.
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A prior use of oral contraceptives has been known to have an inhibitory effect on ovarian cancer development.
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Stop smoking drug Chantix rates stronger warning from FDA; Type 2 diabetes surgery on the way?; Vytorin study inconclusive; Influenza A virus found resistant to Tamiflu; FDA actions.
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Left main coronary artery stenosis is one of the primary indications for coronary artery bypass graft surgery (CABG). Recently, a number of non-randomized studies and registries have suggested that stenting, using current techniques and devices, may be a feasible alternative to CABG.
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Patients with a positive CT scan for coronary calcium often have a stress test. Askew and colleagues from the Mayo Clinic asked whether such patients should undergo repeat stress testing if the first one is negative or low risk?
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The differentiation of constrictive pericarditis from restrictive cardiomyopathy can be difficult, but the treatment implications are great.
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Anticoagulation with vitamin k antagonists is the standard recommendation for patients with nonvalvular atrial fibrillation and risk factors for stroke. The benefits of warfarin in such patients have been well shown in many clinical trials. Therapy with warfarin, however, is often complicated by the dietary and drug interactions, so that even with frequent monitoring, precise control of the anticoagulation level is difficult.
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