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Women older than age 70 comprise 15-20% of breast cancer patients. Some of these older patients may not be able to tolerate or do not desire the standard surgical procedures of either lumpectomy or mastectomy.
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In a multicenter, Italian, randomized, phase III trial, single-agent vinorelbine or gemcitabine proved to be as effective as a combination of the 2 agents in the treatment of advanced non-small-cell lung cancer occurring in patients 70 years and older.
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Postmenopausal estrogen-progestin therapy increased the risk of breast cancer in a population-based cohort in Sweden, and estrogen-only did not.
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Platinum-based adjuvant chemotherapy improved overall survival and recurrence-free survival at 5 years in this combined group of patients with early-stage ovarian cancer defined by the inclusion criteria of the ICON1 and ACTION trials.
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The standard of care for early lung cancer is surgery. However, in aged or frail patients, or in those whose pulmonary or cardiac status is compromised, radical surgery may be contraindicated.
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Although gemcitabine has been proven to be of value in the treatment of advanced pancreatic cancer, remission rates remain low and survival is measured in weeks to months. Swiss investigators report the results from a phase I/II study of combined gemcitabine/capecitabine treatment.
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Taylor and associates report a case of Hashimoto encephalopathy in an adolescent girl with a 9-month history of what was initially diagnosed as chronic fatigue syndrome.
