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Synopsis: The hazard ratio for death from breast cancer for patients with high total cyclin E levels as compared with those with low total cyclin E levels was 13.3 to about 8 times as high as the hazard ratios associated with other independent clinical and pathological risk factors, including axillary node status.
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Synopsis: Involvement of a gynecologic oncologist at the time of primary surgery for endometrial cancer was associated with comparable outcomes in both the university and community hospital setting.
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Synopsis: Sertraline was significantly more effective than placebo when taken during the luteal phase for PMDD.
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Synopsis: Women with pregestational diabetes or gestational diabetes plus fasting hyperglycemia have a 3- to 4-fold increased risk of infant malformations, whereas women with mild gestational diabetes have malformation rates no different than the general nondiabetic obstetric population.
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Synopsis: Combination chemotherapy and extensive radiotherapy introduced in the late 1960s greatly improved survival rates in Hodgkins disease (HD), but increased risk of second cancer was recognized from the early 1970s.
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Eltabbakh retrospectively reviewed women presenting with clinical stage I endometrial cancer (according to the 1988 FIGO staging) at the University of Vermont. Women treated with laparoscopic surgery were compared with those treated with laparotomy with regard to their characteristics, surgical procedure, treatment, surgical stage, histology, tumor grade, and recurrence-free and overall survival.
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After years of legal wrangling, the FDA has approved loratadine (Claritin, Schering-Plough) as an over-the-counter (OTC) product for the treatment of seasonal rhinitis.
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Synopsis: Of 217 consecutive Hodgkins disease patients seen at M.D. Anderson with Stage I or II disease who received chemo- and radiation therapy, 12 had elevated b2M (> 2.5 mg/L). There was a trend for reduced relapse-free survival for those with elevated levels, and a significant correlation with reduced overall survival. Thus, an inexpensive and widely available laboratory measure might provide useful prognostic information in patients with Hodgkins disease.
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Synopsis: The hazard ratio for death from breast cancer for patients with high total cyclin E levels as compared with those with low total cyclin E levels was 13.3 to about 8 times as high as the hazard ratios associated with other independent clinical and pathological risk factors, including axillary node status.
